2

    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON OCTOBER 24, 2003

                                                REGISTRATION NO.  333-108191

                UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                           AMENDMENT NO. 2 TO FORM S-3

             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                                  I-TRAX, INC.
                   ------------------------------------------
             (Exact name of registrant as specified in its charter)

                                    Delaware
                   ------------------------------------------
         (State or other jurisdiction of incorporation or organization)

                                   23-3057155
                   ------------------------------------------
                      (I.R.S. Employer Identification No.)

                          ONE LOGAN SQUARE, SUITE 2615
                               130 N. 18TH STREET
                        PHILADELPHIA, PENNSYLVANIA 19103
                                 (215) 557-7488
 -------------------------------------------------------------------------------
   (Address, including zip code, and telephone number, including are code, of
                    registrant's principal executive offices)

                                 FRANK A. MARTIN
                      CHAIRMAN AND CHIEF EXECUTIVE OFFICER
                                  I-TRAX, INC.
                  ONE LOGAN SQUARE, SUITE 2615, 130 N. 18TH ST.
                             PHILADELPHIA, PA 19103
                               (215) 557-7488 x110
 -------------------------------------------------------------------------------
 (Name, address, including zip code, and telephone number, including are code,
                              of agent for service)

                                   COPIES TO:

YURI ROZENFELD, ESQ.                    JUSTIN P. KLEIN, ESQ.
GENERAL COUNSEL                         GERALD GUARCINI, ESQ.
I-TRAX, INC.                            BALLARD SPAHR ANDREWS & INGERSOLL, LLP
ONE LOGAN SQUARE, SUITE 2615            1735 MARKET STREET, 51ST FLOOR
130 N. 18TH ST.                         PHILADELPHIA, PA  19103
PHILADELPHIA, PA 19103                  (215) 665-8500
(215) 557-7488 x116

Approximate date of commencement of proposed sale to the public: As soon as
practicable after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant
to dividend or interest reinvestment plan, please check the following box. [ ]

If any of the securities being registered on this Form are to be offered on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. [X]




If this Form is filed to register additional securities for an offering pursuant
to Rule 462(b) under the Securities Act, please check the following box and list
the Securities Act registration statement number of the earlier effective
registration statement for the same offering. [ ]

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under
the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering. [ ]

If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. [ ]

                        ________________________________

The registrant hereby amends the registration statement on such date or dates as
may be necessary to delay its effective date until the registrant shall file a
further amendment which specifically states that this registration statement
shall thereafter become effective in accordance with section 8(a) of the
Securities Act of 1933 or until the registration statement shall become
effective on such date as the Commission, acting pursuant to said section 8(a),
may determine.

                                       2





PART II  INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION

         The following table sets forth the costs and expenses payable by I-trax
in connection with the sale of the securities being registered. All amounts are
estimates except the SEC registration fee:

            SEC registration fee                                      $  $373
            Printing and engraving expenses                             1,000
            Accounting fees and expenses                                6,000
            Attorneys' fees and expenses                                2,000
            Transfer agent's fees and expenses                          1,000
            Miscellaneous                                                 627
                                                                --------------

                     Total:                                         $  11,000



ITEM 15. INDEMNIFICATION OF OFFICERS AND DIRECTORS

         Section 145(a) of the Delaware General  Corporation Law provides that a
Delaware  corporation  may  indemnify  any  person  who was or is a party  or is
threatened to be made a party to any  threatened,  pending or completed  action,
suit or proceeding,  whether civil,  criminal,  administrative or investigative,
other  than an action by or in the  right of the  corporation,  by reason of the
fact that he is or was a director, officer, employee or agent of the corporation
or is or was serving at the request of the  corporation as a director,  officer,
employee  or agent of  another  corporation  or  enterprise,  against  expenses,
judgments, fines and amounts paid in settlement actually and reasonably incurred
by him in  connection  with such action,  suit or proceeding if he acted in good
faith and in a manner he reasonably believed to be in or not opposed to the best
interests  of the  corporation  and,  with  respect  to any  criminal  action or
proceeding, had no cause to believe his conduct was unlawful.

         Section 145(b) of the Delaware General  Corporation Law provides that a
Delaware  corporation  may  indemnify  any  person  who was or is a party  or is
threatened to be made a party to any threatened,  pending or completed action or
suit by or in the right of the corporation to procure a judgment in its favor by
reason of the fact that such  person  acted in any of the  capacities  set forth
above,  against expenses  actually and reasonably  incurred by him in connection
with the defense or  settlement of such action or suit if he acted in good faith
and in a manner  he  reasonably  believed  to be in or not  opposed  to the best
interests  of the  corporation,  except that no  indemnification  may be made in
respect of any claim,  issue or matter as to which such  person  shall have been
adjudged to be liable to the corporation  unless and only to the extent that the
court in which such action or suit was brought  shall  determine  that,  despite
such adjudication of liability, such person is fairly and reasonably entitled to
be indemnified for such expenses which the court shall deem proper.

         Section 145 of the Delaware  General  Corporation Law further  provides
that to the extent a director  or  officer  of a Delaware  corporation  has been
successful  in the  defense of any  action,  suit or  proceeding  referred to in
subsections  (a) or (b) of Section 145 or in the defense of any claim,  issue or
matter  therein,  he shall be  indemnified  against any  expenses  actually  and
reasonably  incurred by him in connection  therewith;  that the  indemnification
provided for by Section 145 shall not be deemed exclusive of any rights to which
the  indemnified  party may be entitled  and the  corporation  may  purchase and
maintain insurance on behalf of a director or officer of the corporation against
any  liability  asserted  against him or incurred by him in any such capacity or
arising out of his status as such whether or not the corporation  would have the
power to indemnify him against such liabilities under Section 145.

         Section  102(b)(7) of the Delaware  General  Corporation  Law permits a
Delaware corporation to include a provision in its Certificate of Incorporation,
and I-trax's  Certificate  of  Incorporation  contains such a provision,  to the
effect that, subject to certain exceptions, a director of a Delaware corporation
is not personally  liable to the  corporation or its  stockholders  for monetary
damages for a breach of his fiduciary duty as a director.

                                     -II-1-




I-trax's  By-laws also provide that I-trax shall  indemnify  its  directors  and
officers  and,  to the  extent  permitted  by the Board of  Directors,  I-trax's
employees  and  agents,  to the  full  extent  permitted  by  and in the  manner
permissible  under  the laws of the State of  Delaware.  In  addition,  I-trax's
By-laws  permit the Board of Directors to authorize  the Company to purchase and
maintain  insurance against any liability  asserted against any of the Company's
directors, officers, employees or agents arising out of their capacity as such.

ITEM 16. EXHIBITS

           NUMBER       EXHIBIT TITLE
           ------       -------------

            4.1*        Convertible  Promissory  Note of I-trax,  Inc. issued to
                        Joseph Shamy and Greta Shamy JT on March 30, 2003.

            4.2*        Warrant  certificate  of I-trax,  Inc.  issued to Joseph
                        Shamy and Greta Shamy JT on March 30, 2003.

            4.3*        Form of warrant  certificate of I-trax,  Inc.  issued to
                        each of Michael  Steinberg  and Barry  Honing on June 2,
                        2003.

            5**         Opinion  of  Vice   President,   General   Counsel   and
                        Secretary.

            23.1**      Consent  of  Vice   President,   General   Counsel   and
                        Secretary. (Included in Exhibit 5.)

            23.2*       Consent of Goldstein Golub Kessler LLP.

            23.3*       Consent of PricewaterhouseCoopers LLP.

            24          Power of Attorney. (Included in signature page.)

         _____________________________
         *              Previously filed.
         **             Filed with this registration statement.

ITEM 17.          UNDERTAKINGS

         The undersigned registrant hereby undertakes to:

         (1) File, during any period in which it offers or sells securities, a
post-effective amendment to this registration statement to include any
additional or changed material information on the plan of distribution.

         (2) For determining liability under the Securities Act, treat each
post-effective amendment as a new registration statement of the securities
offered, and the offering of the securities at that time to be the initial bona
fide offering.

         (3) File a post-effective amendment to remove from registration any of
the securities that remain unsold at the end of the offering.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors,  officers and controlling  persons of
the small business  issuer pursuant to the foregoing  provisions,  or otherwise,
the small business issuer has been advised that in the opinion of the Securities
and  Exchange  Commission  such  indemnification  is  against  public  policy as
expressed in the Act and is, therefore, unenforceable. In the event that a claim
for  indemnification  against  such  liabilities  (other than the payment by the
small  business  issuer of expenses  incurred or paid by a director,  officer or
controlling person of the small business issuer in the successful defense of any
action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities  being  registered,  the small business
issuer will, unless in the opinion of its counsel the matter has been settled by
controlling  precedent,  submit  to a  court  of  appropriate  jurisdiction  the
question  whether  such

                                     -II-2-




indemnification  by it is against  public policy as expressed in the  Securities
Act and will be governed by the final adjudication of such issue.




                                     -II-3-




                                   SIGNATURES

         Pursuant  to the  requirements  of the  Securities  Act  of  1933,  the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements of filing of this Registration Statement on Form S-3 and has
duly  caused  this  registration  statement  to be singed  on its  behalf by the
undersigned, thereunto duly authorized in the City of Philadelphia, Commonwealth
of Pennsylvania on October 24, 2003.

                         I-TRAX, INC.

                         By:      /s/ Frank A. Martin
                                  -----------------------------
                                  Frank A. Martin, Chairman and
                                  Chief Executive Officer

                         By:      /s/ William S. Wheeler
                                  ------------------------
                                  William S. Wheeler, Chief Financial Officer
                                  (Principal Financial and Accounting Officer)

         In accordance with the requirements of the Securities Act of 1933, this
Registration  Statement on Form S-3 was signed by the  following  persons in the
capacities and on the dates stated.

         Each person  whose  signature  appears  below in so signing also makes,
constitutes  and  appoints  Frank A. Martin and  William S.  Wheeler and each of
them,  his  or  her  true  and  lawful  attorney-in-fact,  with  full  power  of
substitution,  for him or her in any and all capacities, to execute and cause to
be filed with the Securities and Exchange  Commission any and all amendments and
post-effective  amendments  to  this  Registration  Statement  and  any  related
registration statement (and any and all amendments and post-effective amendments
thereto)  contemplated by Rule 462 under the Securities Act of 1933, as amended,
in each case with exhibits  thereto and other documents in connection  therewith
and hereby  ratifies and confirms all that said  attorney-in-fact  or his or her
substitute or substitutes may do or cause to be done by virtue hereof.





Signature                                Title                                  Date
-------------------                      ---------------------------------      ----------------
                                                                                      
/s/ Frank A. Martin                      Chairman, Chief Executive Officer,     October 24, 2003
-------------------                      President and Director
Frank A. Martin

*                                        Director                               October 24, 2003
-------------------
John Blazek

*                                        Director                               October 24, 2003
-------------------
David R. Bock

*                                        Director                               October 24, 2003
-------------------
Philip D. Green

*                                        Director                               October 24, 2003
------------------------
Dr. Michael M.E. Johns

*                                        Director                               October 24, 2003
------------------------
Dr. Arthur N. Leibowitz

*                                        Director                               October 24, 2003
------------------------
Dr. David Nash

*                                        Director                               October 24, 2003
------------------------
John R. Palumbo

                                     -II-4-




*                                        Director                               October 24, 2003
------------------------
R. Dixon Thayer

/s/ William S. Wheeler                   Director                               October 24, 2003
------------------------
William S. Wheeler


*By: Frank A. Martin, Attorney in Fact.
     ---------------



                                     -II-5-