SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                 SCHEDULE 13G/A
                                 (Rule 13d-102)
                                (Amendment No. 2)
           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
            RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)


                          METABASIS THERAPEUTICS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                         Common Stock, $0.001 par value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    59101M105
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2006
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check  the  appropriate  box to  designate  the  rule  pursuant  to  which  this
Schedule is filed:

      [X]   Rule 13d-1(b)
      [_]   Rule 13d-1(c)
      [_]   Rule 13d-1(d)

*The  remainder of this cover page shall be filled out for a reporting  person's
initial  filing on this form with  respect to the subject  class of  securities,
and for any  subsequent  amendment  containing  information  which  would  alter
disclosures provided in a prior cover page.

The  information  required  on the  remainder  of this  cover  page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 ("Act") or otherwise  subject to the  liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however,  see
the Notes).


                                    1 of 10



---------------------                                   ------------------------
                     |                                 |
CUSIP No. 59101M105  |                13G/A            |
                     |                                 |
---------------------                                   ------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          Maverick Capital, Ltd. - 75-2482446
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |_|
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     CITIZENSHIP OR PLACE OF ORGANIZATION

          Texas
--------------------------------------------------------------------------------
                |   5      SOLE VOTING POWER
                |          507,267
 NUMBER OF      ---------------------------------------------------------------
   SHARES       |   6      SHARED VOTING POWER
BENEFICIALLY    |          0
  OWNED BY      ----------------------------------------------------------------
    EACH        |   7      SOLE DISPOSITIVE POWER
 REPORTING      |          507,267
PERSON WITH     ----------------------------------------------------------------
                |   8      SHARED DISPOSITIVE POWER
                |          0
--------------------------------------------------------------------------------
    9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          507,267
--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES*                                              |_|
--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          1.7%
--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IA
--------------------------------------------------------------------------------

      *SEE INSTRUCTIONS BEFORE FILLING OUT


                                    2 of 10



---------------------                                   ------------------------
                     |                                 |
CUSIP No. 59101M105  |                13G/A            |
                     |                                 |
---------------------                                   ------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          Maverick Capital Management, LLC - 75-2686461
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |_|
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     CITIZENSHIP OR PLACE OF ORGANIZATION

          Texas
--------------------------------------------------------------------------------
                |   5      SOLE VOTING POWER
                |          507,267
 NUMBER OF      ---------------------------------------------------------------
   SHARES       |   6      SHARED VOTING POWER
BENEFICIALLY    |          0
  OWNED BY      ----------------------------------------------------------------
    EACH        |   7      SOLE DISPOSITIVE POWER
 REPORTING      |          507,267
PERSON WITH     ----------------------------------------------------------------
                |   8      SHARED DISPOSITIVE POWER
                |          0
--------------------------------------------------------------------------------
    9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          507,267
--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES*                                              |_|
--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          1.7%
--------------------------------------------------------------------------------
  12     TYPE OF REPORTING PERSON*

          HC
--------------------------------------------------------------------------------

      *SEE INSTRUCTIONS BEFORE FILLING OUT



                                    3 of 10



---------------------                                   ------------------------
                     |                                 |
CUSIP No. 59101M105  |                13G/A            |
                     |                                 |
---------------------                                   ------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSONS
          I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

          Lee S. Ainslie III
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |_|
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States
--------------------------------------------------------------------------------
                |   5      SOLE VOTING POWER
                |          507,267
 NUMBER OF      ---------------------------------------------------------------
   SHARES       |   6      SHARED VOTING POWER
BENEFICIALLY    |          0
  OWNED BY      ----------------------------------------------------------------
    EACH        |   7      SOLE DISPOSITIVE POWER
 REPORTING      |          507,267
PERSON WITH     ----------------------------------------------------------------
                |   8      SHARED DISPOSITIVE POWER
                |          0
--------------------------------------------------------------------------------
    9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          507,267
--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
          CERTAIN SHARES*                                              |_|
--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          1.7%
--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          HC
--------------------------------------------------------------------------------

      *SEE INSTRUCTIONS BEFORE FILLING OUT


                                    4 of 10



Item 1(a)   Name of Issuer.

            Metabasis Therapeutics, Inc.

Item 1(b)   Address of Issuer's Principal Executive Offices.

            11119 North Torrey Pines Road
            La Jolla, California  92037

Item 2(a)   Name of Person Filing.

            This Schedule 13G (the  "Schedule  13G") is being filed on behalf of
            each of the following persons (each, a "Reporting Person"):

            (i)   Maverick Capital, Ltd.;

            (ii)  Maverick Capital Management, LLC; and

            (iii) Lee S. Ainslie III ("Mr. Ainslie").

            The  Schedule  13G  relates to Shares (as defined  herein)  held for
            the accounts of Maverick Capital, Ltd.'s clients.


Item 2(b)   Address of Principal Business Office, or, if none, Residence.

            The  address  of the  principal  business  office  of  (i)  Maverick
            Capital,  Ltd. and Maverick Capital Management,  LLC is 300 Crescent
            Court,  18th Floor,  Dallas,  Texas 75201,  and (ii) Mr.  Ainslie is
            767 Fifth Avenue, 11th Floor, New York, New York 10153.


Item 2(c)   Citizenship or Place of Organization.

            (i)   Maverick Capital, Ltd. is a Texas limited partnership;

            (ii)  Maverick Capital Management, LLC is a Texas limited liability
                  company; and

            (iii) Mr. Ainslie is a citizen of the United States.

Item 2(d)   Title of Class of Securities.

            Common Stock, $0.001 par value (the "Shares").

Item 2(e)   CUSIP Number.

            59101M105


                                    5 of 10



Item 3.     If  this   statement  is  filed   pursuant  to   ss.ss.240.13d-1(b)
            or 240.13d-2(b) or (c), check whether the person filing is a:

  (a)  [_]  Broker or dealer registered under section 15 of the Act (15 U.S.C.
            78o).

  (b)  [_]  Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

  (c)  [_]  Insurance company as defined in section 3(a)(19) of the Act (15
            U.S.C. 78c).

  (d)  [_]  Investment company registered under section 8 of the Investment
            Company Act of 1940 (15 U.S.C. 80a-8).

  (e)  [X]  An investment advisor in accordance with s.240.13d-1(b)(1)(ii)(E).

  (f)  [_]  An employee benefit plan or endowment fund in accordance with
            ss.240.13d-1(b)(1)(ii)(F).

  (g)  [X]  A parent holding company or control person in accordance with
            ss.240.13d-1(b)(1)(ii)(G).

  (h)  [_]  A savings association as defined in Section 3(b) of the Federal
            Deposit Insurance Act (12 U.S.C. 1813).

  (i)  [_]  A church plan that is excluded from the definition of an
            investment company under Section 3(c)(14) of the Investment
            Company Act of 1940 (15 U.S.C. 80a-3).

  (j)  [_]  Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

Item 4      Ownership.

            Ownership  as of December 31, 2006 is  incorporated  by reference to
            items (5) - (9) and (11) of the cover page of the Reporting Person.


Item 5      Ownership of Five Percent or Less of a Class.

            If this  statement  is being filed to report the fact that as of the
            date  hereof the  reporting  person has ceased to be the  beneficial
            owner of more than five  percent of the class of  securities,  check
            the following:                      [X]

Item 6      Ownership of More Than Five Percent on Behalf of Another Person.

            Not applicable.

Item 7      Identification  and  Classification of the Subsidiary which Acquired
            the Security Being Reported On by the Parent Holding Company.

            Not applicable.

Item 8      Identification and Classification of Members of the Group.

            Not applicable.


                                    6 of 10



Item 9      Notice of Dissolution of Group.

            Not applicable.

Item 10     Certification.

            By signing below each of the Reporting  Persons  certifies  that, to
            the best of such  person's  knowledge,  and belief,  the  securities
            referred  to  above  were  acquired  and are  held  in the  ordinary
            course of business  and were not  acquired  and are not held for the
            purpose  of or with  the  effect  of  changing  or  influencing  the
            control of the issuer of the  securities  and were not  acquired and
            are  not  held  in  connection  with  or  as a  participant  in  any
            transaction having that purpose or effect.


                                   SIGNATURE

      After  reasonable  inquiry and to the best of my knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


Date: February 14, 2007       MAVERICK CAPITAL, LTD.

                              By: Maverick Capital Management, LLC
                                  Its General Partner

                                  By: Lee S. Ainslie III, Manager



                                      By: /s/John T. McCafferty
                                          -----------------------------
                                          John T. McCafferty
                                          Under Power of Attorney dated
                                          February 13, 2003


Date: February 14, 2007       MAVERICK CAPITAL MANAGEMENT, LLC

                              By: Lee S. Ainslie III, Manager



                                  By: /s/John T. McCafferty
                                      ---------------------------------
                                      John T. McCafferty
                                      Under Power of Attorney dated
                                      February 13, 2003


                                     7 of 10



Date: February 14, 2007       LEE S. AINSLIE III



                              By: /s/John T. McCafferty
                                  -------------------------------------
                                  John T. McCafferty
                                  Under Power of Attorney dated
                                  February 13, 2003




                                    8 of 10



                                 EXHIBIT INDEX

A.    Joint Filing  Agreement,  dated  February 14, 2005, by and among  Maverick
      Capital, Ltd., Maverick Capital Management, LLC, and Lee S. Ainslie III.




                                    9 of 10



                                                                       Exhibit A

                             Joint Filing Agreement

      The  undersigned  hereby  agree that the  statement  on Schedule  13G with
respect  to the  Common  Stock,  $0.001  par  value of  Metabasis  Therapeutics,
Inc., dated as of February 14, 2005, is, and any amendments  thereto  (including
amendments  on Schedule 13D) signed by each of the  undersigned  shall be, filed
on behalf of each of us pursuant to and in  accordance  with the  provisions  of
Rule 13d-1(k) under the Securities Exchange Act of 1934.


Date: February 14, 2005


                              MAVERICK CAPITAL, LTD.

                              By: Maverick Capital Management, LLC
                                  Its General Partner

                                  By: Lee S. Ainslie III, Manager



                                      By: /s/John T. McCafferty
                                          -----------------------------
                                          John T. McCafferty
                                          Under Power of Attorney dated
                                          February 13, 2003


                              MAVERICK CAPITAL MANAGEMENT, LLC

                              By: Lee S. Ainslie III, Manager



                                  By: /s/John T. McCafferty
                                      ---------------------------------
                                      John T. McCafferty
                                      Under Power of Attorney dated
                                      February 13, 2003


                              LEE S. AINSLIE III



                              By: /s/John T. McCafferty
                                  -------------------------------------
                                  John T. McCafferty
                                  Under Power of Attorney dated
                                  February 13, 2003