SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

                    INFORMATION TO BE INCLUDED IN STATEMENTS
                   FILED PURSUANT TO RULES 13d-1(b), (c), AND
                           (d) AND AMENDMENTS THERETO
                         FILED PURSUANT TO RULE 13d-2(b)
                               (Amendment No. 1)*


                               Nektar Therapeutics
                         ------------------------------

                                (Name of Issuer)

                                  Common Stock
                         ------------------------------

                         (Title of Class of Securities)

                                    640268108
                         ------------------------------
                                 (CUSIP Number)

                                DECEMBER 31, 2007
             -------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
                               Schedule is filed:

                                (x) Rule 13d-1(b)
                                ( ) Rule 13d-1(c)
                                ( ) Rule 13d-1(d)

----------------
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                        (Continued on following page(s))





1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     TIAA-CREF Investment Management, LLC
     I.R.S. #13-3586142

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                   (a) ( )
                                                                        (b) ( )

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5. SOLE VOTING POWER                   682,244

         6. SHARED VOTING POWER                 0

         7. SOLE DISPOSITIVE POWER              682,244

         8. SHARED DISPOSITIVE POWER            0

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                                682,244

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ( )

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                0.74 %

12.  TYPE OF REPORTING PERSON

                                IA





1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Teachers Advisors, Inc.
     I.R.S. # 13-3760073

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                   (a) ( )
                                                                        (b) ( )

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     Delaware

NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH:

         5. SOLE VOTING POWER                 72,927

         6. SHARED VOTING POWER               0

         7. SOLE DISPOSITIVE POWER            72,927

         8. SHARED DISPOSITIVE POWER          0

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
                                   72,927

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES ( )


11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                                   0.08 %

12.  TYPE OF REPORTING PERSON

                                   IA





Item 1(a).     NAME OF ISSUER:

                  Nektar Therapeutics

Item 1(b).     ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

                  150 Industrial Road
                  San Carlos, CA 94070


Items 2(a)-2(c).  NAME, ADDRESS OF PRINCIPAL BUSINESS OFFICE, AND CITIZENSHIP
                  OF PERSONS FILING:

                  TIAA-CREF Investment Management, LLC ("Investment Management")
                  730 Third Avenue
                  New York, NY 10017
                  Citizenship: Delaware

                  Teachers Advisors, Inc. ("Advisors")
                  730 Third Avenue
                  New York, NY 10017
                  Citizenship: Delaware


Item 2(d).     TITLE OF CLASS OF SECURITIES:

                  Common Stock

Item 2(e).     CUSIP NUMBER:  640268108

Item 3.        IF THIS STATEMENT IS FILED PURSUANT TO RULES 13d-1(b), OR
               13d-2(b) or (c), CHECK WHETHER THE PERSON FILING IS A:

INVESTMENT MANAGEMENT

(a)   ( )      Broker or dealer registered under Section 15 of the Exchange Act.

(b)   ( )      Bank as defined in Section 3(a)(6) of the Exchange Act.

(c)   ( )      Insurance Company as defined in Section 3(a)(19) of the Exchange
               Act.

(d)   ( )      Investment Company registered under Section 8 of the Investment
               Company Act.

(e)   (x)      An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

(f)   ( )      An employee benefit plan or endowment fund in accordance with
               Rule 13d-1(b)(1)(ii)(F).

(g)   ( )      A parent holding company or control person in accordance with
               Rule 13d-1(b)(1)(ii)(G).

(h)   ( )      A savings association as defined in Section 3(b) of the Federal
               Deposit Insurance Act.

(i)   ( )      A church plan that is excluded from the definition of an
               investment company under Section 3(c)(14) of the Investment
               Company Act.

(j)   ( )      Group, in accordance with Rule 13d-1(b)(1)(ii)(J).





ADVISORS

(a)   ( )      Broker or dealer registered under Section 15 of the Exchange Act.

(b)   ( )      Bank as defined in Section 3(a)(6) of the Exchange Act.

(c)   ( )      Insurance Company as defined in Section 3(a)(19) of the Exchange
               Act.

(d)   ( )      Investment Company registered under Section 8 of the Investment
               Company Act.

(e)   (x)      An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

(f)   ( )      An employee benefit plan or endowment fund in accordance with
               Rule 13d-1(b)(1)(ii)(F).

(g)   ( )      A parent holding company or control person in accordance with
               Rule 13d-1(b)(1)(ii)(G).

(h)   ( )      A savings association as defined in Section 3(b) of the Federal
               Deposit Insurance Act.

(i)   ( )      A church plan that is excluded from the definition of an
               investment company under Section 3(c)(14) of the Investment
               Company Act.

(j)   ( )      Group, in accordance with Rule 13d-1(b)(1)(ii)(J).


If this statement is filed pursuant to Rule 13d-1(c), check this box. ( )

Item 4.        OWNERSHIP

               (a) Aggregate amount beneficially owned: 755,171 (See Exhibit A)

               (b) Percent of class:                    0.74 %

               (c) Powers of shares:

                                    INVESTMENT MANAGEMENT              ADVISORS
                                    ---------------------              --------
Sole Voting Power:                  682,244                            72,927

Shared Voting Power:                0                                  0

Sole Dispositive Power:             682,244                            72,927

Shared Dispositive Power:           0                                  0

Item 5.        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

               If this statement is being filed to report the fact that as of
               the date hereof the reporting person has ceased to be the
               beneficial owner of more than five percent of the class of
               securities, check the following (x). See Exhibit A

Item 6.        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

               Not Applicable

Item 7.        IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
               ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
               COMPANY.




               Not Applicable

Item 8.        IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

               Not Applicable

Item 9.        NOTICE OF DISSOLUTION OF GROUP.

               Not Applicable


Item 10.       CERTIFICATION.

               By signing below I certify that, to the best of my knowledge and
               belief, the securities referred to above were acquired and are
               held in the ordinary course of business and were not acquired and
               are not held for the purpose of or with the effect of changing or
               influencing the control of the issuer of the securities and were
               not acquired and are not held in connection with or as a
               participant in any transaction having that purpose or effect.


               SIGNATURE.

               After reasonable inquiry and to the best of my knowledge and
               belief, I certify that the information set forth in this
               statement is true, complete and correct.

               Date: February 14, 2008

                                                 TIAA-CREF INVESTMENT
                                                 MANAGEMENT, LLC

                                                 By: /s/ Michael Albert
                                                     -------------------------
                                                 Michael Albert
                                                 Managing Director


                                                 TEACHERS ADVISORS, INC.

                                                 By: /s/ MICHAEL ALBERT
                                                     -------------------------
                                                 Michael Albert
                                                 Managing Director






                                    EXHIBIT A


ITEM 6.  OWNERSHIP.

TIAA-CREF Investment Management, LLC ("Investment Management") acts as an
investment adviser to the College Retirement Equities Fund ("CREF"), a
registered investment company, and may be deemed to be a beneficial owner of
682,244 shares of Issuer's common stock owned by CREF. Teachers Advisors, Inc.
("Advisors") is the investment adviser to three registered investment companies,
TIAA-CREF Institutional Mutual Funds ("Institutional Funds"), TIAA-CREF Life
Funds ("Life Funds"), and TIAA Separate Account VA-1 ("VA-1"), as well as the
TIAA-CREF Asset Management Commingled Funds Trust I ("TCAM Funds"), and may be
deemed to be a beneficial owner of 72,927 shares of Issuer's common stock owned
by Institutional Funds, Life Funds, VA-1 and TCAM Funds. Investment Management
and Advisors are reporting their combined holdings for the purpose of
administrative convenience. These shares were acquired in the ordinary course of
business, and not with the purpose or effect of changing or influencing control
of the Issuer. Each of Investment Management and Advisors expressly disclaims
beneficial ownership of the other's securities holdings and each disclaims that
it is a member of a "group" with the other.