1 |
NAME OF REPORTING PERSON
Biotechnology Value Fund, L.P. | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
WC | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
848,521 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
848,521 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
848,521 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
3.5% | ||
14 |
TYPE OF REPORTING PERSON
PN |
1 |
NAME OF REPORTING PERSON
Biotechnology Value Fund II, L.P. | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
WC | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
588,000 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
588,000 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
588,000 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
2.4% | ||
14 |
TYPE OF REPORTING PERSON
PN |
1 |
NAME OF REPORTING PERSON
BVF Investments, L.L.C. | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
WC | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
2,036,000 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
2,036,000 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
2,036,000 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
8.3% | ||
14 |
TYPE OF REPORTING PERSON
OO |
1 |
NAME OF REPORTING PERSON
Investment 10, L.L.C. | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
WC | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
Illinois | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
211,000 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
211,000 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
211,000 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
LESS THAN 1% | ||
14 |
TYPE OF REPORTING PERSON
OO |
1 |
NAME OF REPORTING PERSON
BVF Partners L.P. | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
OO | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
3,683,521 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
3,683,521 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,683,521 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
14.998% | ||
14 |
TYPE OF REPORTING PERSON
PN, IA |
1 |
NAME OF REPORTING PERSON
BVF Inc. | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
OO | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
3,683,521 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
3,683,521 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,683,521 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
14.998% | ||
14 |
TYPE OF REPORTING PERSON
CO |
1 |
NAME OF REPORTING PERSON
Mark N. Lampert | ||
2 |
CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
(a) x
(b) o | |
3 |
SEC USE ONLY
| ||
4 |
SOURCE OF FUNDS
OO | ||
5 |
CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) OR 2(e)
|
¨ | |
6 |
CITIZENSHIP OR PLACE OF ORGANIZATION
USA | ||
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH |
7 |
SOLE VOTING POWER
0 | |
8 |
SHARED VOTING POWER
3,683,521 | ||
9 |
SOLE DISPOSITIVE POWER
0 | ||
10 |
SHARED DISPOSITIVE POWER
3,683,521 | ||
11 |
AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
3,683,521 | ||
12 |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
|
o | |
13 |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
14.998% | ||
14 |
TYPE OF REPORTING PERSON
IN |
Item 1. |
Security and Issuer. |
Item 2. |
Identity and Background. |
Source and Amount of Funds or Other Consideration. |
Purpose of Transaction |
Interest in Securities of the Issuer. |
Item 6. |
Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer. |
Item 7. |
Material to be Filed as Exhibits. |
|
99.1 |
Joint Filing Agreement by and among Biotechnology Value Fund, L.P., Biotechnology Value Fund II, L.P., BVF Investments, L.L.C., Investment 10, L.L.C., BVF Partners L.P., BVF Inc. and Mark N. Lampert, dated September 29, 2009. |
BIOTECHNOLOGY VALUE FUND, L.P. |
INVESTMENT 10, L.L.C. | |||
By: |
BVF Partners L.P., its general partner |
By: |
BVF Partners L.P., its investment manager | |
By: |
BVF Inc., its general partner |
By: |
BVF Inc., its general partner | |
By: |
/s/ Mark N. Lampert |
By: |
/s/ Mark N. Lampert | |
Mark N. Lampert |
Mark N. Lampert | |||
President |
President |
BIOTECHNOLOGY VALUE FUND II, L.P. |
BVF PARTNERS L.P. | |||
By: |
BVF Partners L.P., its general partner |
By: |
BVF Inc., its general partner | |
By: |
BVF Inc., its general partner |
By: |
/s/ Mark N. Lampert | |
Mark N. Lampert | ||||
By: |
/s/ Mark N. Lampert |
President | ||
Mark N. Lampert |
||||
President |
BVF INVESTMENTS, L.L.C. |
BVF INC. | |||
By: |
BVF Partners L.P., its manager |
By: |
/s/ Mark N. Lampert | |
Mark N. Lampert | ||||
By: |
BVF Inc., its general partner |
President | ||
By: |
/s/ Mark N. Lampert |
|||
Mark N. Lampert |
/s/ Mark N. Lampert | |||
President |
MARK N. LAMPERT |
Class of
Security |
Securities
Purchased |
Price ($) |
Date of
Purchase |
Common Stock |
29,000 |
8.2547 |
07/27/09 | |
Common Stock |
9,800 |
8.3802 |
07/28/09 | |
Common Stock |
13,200 |
8.5603 |
07/29/09 | |
Common Stock |
3,600 |
8.7951 |
07/31/09 | |
Common Stock |
1,500 |
8.8000 |
08/03/09 | |
Common Stock |
23,000 |
10.2625 |
08/05/09 | |
Common Stock |
287,000 |
16.2476 |
09/08/09 |
Common Stock |
19,000 |
8.2547 |
07/27/09 | |
Common Stock |
7,000 |
8.3802 |
07/28/09 | |
Common Stock |
9,000 |
8.5603 |
07/29/09 | |
Common Stock |
3,000 |
8.7951 |
07/31/09 | |
Common Stock |
16,000 |
10.2625 |
08/05/09 | |
Common Stock |
199,000 |
16.2476 |
09/08/09 |
Common Stock |
67,000 |
8.2547 |
07/27/09 | |
Common Stock |
24,000 |
8.3802 |
07/28/09 | |
Common Stock |
32,000 |
8.5603 |
07/29/09 | |
Common Stock |
9,000 |
8.7951 |
07/31/09 | |
Common Stock |
1,000 |
8.8000 |
08/03/09 | |
Common Stock |
55,000 |
10.2625 |
08/05/09 | |
Common Stock |
688,000 |
16.2476 |
09/08/09 |
Common Stock |
7,000 |
8.2547 |
07/27/09 | |
Common Stock |
3,000 |
8.3802 |
07/28/09 | |
Common Stock |
3,000 |
8.5603 |
07/29/09 | |
Common Stock |
1,000 |
8.7951 |
07/31/09 | |
Common Stock |
6,000 |
10.2625 |
08/05/09 | |
Common Stock |
71,000 |
16.2476 |
09/08/09 |