SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                                (Amendment No. 1)


                                  CYTOGEN CORP
--------------------------------------------------------------------------------
                                (Name of Issuer)


                          Common Stock, $.01 Par Value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    232824300
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2005
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

     [_] Rule 13d-1(b)

     [x] Rule 13d-1(c)

     [_] Rule 13d-1(d)

----------
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).


CUSIP No. 232824300
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     A. Alex Porter

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [_]
                                                                         (b) [x]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     USA

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     1,350,929

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     1,350,929

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,350,929

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                             [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     6.0119%

12.  TYPE OF REPORTING PERSON*

     IN

--------------------------------------------------------------------------------


CUSIP No. 232824300
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Paul Orlin

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [_]
                                                                         (b) [x]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     USA

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     1,350,929

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     1,350,929

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,350,929

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                          [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     6.0119%

12.  TYPE OF REPORTING PERSON*

     IN

--------------------------------------------------------------------------------


CUSIP No. 232824300
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Geoffrey Hulme

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [_]
                                                                         (b) [x]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     USA

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     1,350,929

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     1,350,929

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,350,929

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                             [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     6.0119%

12.  TYPE OF REPORTING PERSON*

     IN

--------------------------------------------------------------------------------


CUSIP No. 232824300
          ---------

1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

     Jonathan W. Friedland

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [_]
                                                                         (b) [x]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION

     USA

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.   SOLE VOTING POWER

     0

6.   SHARED VOTING POWER

     1,350,929

7.   SOLE DISPOSITIVE POWER

     0

8.   SHARED DISPOSITIVE POWER

     1,350,929

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     1,350,929

10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                             [_]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     6.0119%

12.  TYPE OF REPORTING PERSON*

     IN

--------------------------------------------------------------------------------


 CUSIP No. 232824300
           ---------

Item 1(a).  Name of Issuer:

            CYTOGEN CORP
            --------------------------------------------------------------------

Item 1(b).  Address of Issuer's Principal Executive Offices:

            650 College Road East, Suite 3100
            Princeton, New Jersey 08540
            --------------------------------------------------------------------

Item 2(a).  Name of Person Filing:

            A. Alex Porter
            Paul Orlin
            Geoffrey Hulme
            Jonathan W. Friedland
            --------------------------------------------------------------------

Item 2(b).  Address of Principal Business Office, or if None, Residence:

            666 5th Avenue, 34th Floor, New York, New York 10103
            666 5th Avenue, 34th Floor, New York, New York 10103
            666 5th Avenue, 34th Floor, New York, New York 10103
            666 5th Avenue, 34th Floor, New York, New York 10103
            --------------------------------------------------------------------

Item 2(c).  Citizenship or Place of Organization:

            USA
            USA
            USA
            USA
            --------------------------------------------------------------------

Item 2(d).  Title of Class of Securities:

            Common Stock, $.01 Par Value
            --------------------------------------------------------------------

Item 2(e).  CUSIP Number:

            232824300
            --------------------------------------------------------------------

Item 3.   If This Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) or
          (c), Check Whether the Person Filing is a:

     (a)  [_]  Broker or dealer registered under Section 15 of the Exchange Act.

     (b)  [_]  Bank as defined in Section 3(a)(6) of the Exchange Act.

     (c)  [_]  Insurance company as defined in Section 3(a)(19) of the Exchange
               Act.

     (d)  [_]  Investment company registered under Section 8 of the Investment
               Company Act.

     (e)  [_]  An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

     (f)  [_]  An employee benefit plan or endowment fund in accordance with
               Rule 13d-1(b)(1)(ii)(F);

     (g)  [_]  A parent holding company or control person in accordance with
               Rule 13d-1(b)(1)(ii)(G);

     (h)  [_]  A savings association as defined in Section 3(b) of the Federal
               Deposit Insurance Act;

     (i)  [_]  A church plan that is excluded from the definition of an
               investment company under Section 3(c)(14) of the Investment
               Company Act;

     (j)  [_]  Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

Item 4.   Ownership.

     Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

     (a)  Amount beneficially owned:

          A. Alex Porter: 1,350,929 shares
          Paul Orlin: 1,350,929 shares
          Geoffrey Hulme: 1,350,929 shares
          Jonathan W. Friedland: 1,350,929 shares
          ----------------------------------------------------------------------

     (b)  Percent of class:

          A. Alex Porter: 6.0119%
          Paul Orlin: 6.0119%
          Geoffrey Hulme: 6.0119%
          Jonathan W. Friedland: 6.0119%
          ----------------------------------------------------------------------

     (c)  Number of shares as to which such person has:

          (i)   Sole power to vote or to direct the vote
                                                Alex Porter: 0
                                                Paul Orlin: 0
                                                Geoffrey Hulme: 0
                                                Jonathan W. Friedland: 0
                                                -------------------------------,

          (ii)  Shared power to vote or to direct the vote
                                                Alex Porter: 1,350,929
                                                Paul Orlin: 1,350,929
                                                Geoffrey Hulme: 1,350,929
                                                Jonathan W. Friedland: 1,350,929
                                                -------------------------------,

          (iii) Sole power to dispose or to direct the disposition of
                                                Alex Porter: 0
                                                Paul Orlin: 0
                                                Geoffrey Hulme: 0
                                                Jonathan W. Friedland: 0
                                                -------------------------------,

          (iv)  Shared power to dispose or to direct the disposition of
                                                Alex Porter: 1,350,929
                                                Paul Orlin: 1,350,929
                                                Geoffrey Hulme: 1,350,929
                                                Jonathan W. Friedland: 1,350,929
                                                -------------------------------.

Item 5.   Ownership of Five Percent or Less of a Class.

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities check the following [ ].

          Not Applicable
          ---------------------------------------------------------------------

Item 6.  Ownership of More Than Five Percent on Behalf of Another Person.

     If any other person is known to have the right to receive or the power to
direct the receipt of dividends from, or the proceeds from the sale of, such
securities, a statement to that effect should be included in response to this
item and, if such interest relates to more than five percent of the class, such
person should be identified. A listing of the shareholders of an investment
company registered under the Investment Company Act of 1940 or the beneficiaries
of employee benefit plan, pension fund or endowment fund is not required.

          Not Applicable
          ----------------------------------------------------------------------

Item 7.   Identification and Classification of the Subsidiary Which Acquired the
          Security Being Reported on by the Parent Holding Company or Control
          Person.

     If a parent holding company or Control person has filed this schedule,
pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an
exhibit stating the identity and the Item 3 classification of the relevant
subsidiary. If a parent holding company or control person has filed this
schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating
the identification of the relevant subsidiary.

          Not Applicable
          ----------------------------------------------------------------------

Item 8.   Identification  and  Classification  of Members of the Group.

     If a group has filed this schedule pursuant to ss.240.13d-1(b)(1)(ii)(J),
so indicate under Item 3(j) and attach an exhibit stating the identity and Item
3 classification of each member of the group. If a group has filed this schedule
pursuant to ss.240.13d-1(c) or ss.240.13d-1(d), attach an exhibit stating the
identity of each member of the group.

          Not Applicable
          ----------------------------------------------------------------------

Item 9.   Notice of Dissolution of Group.

     Notice of dissolution of a group may be furnished as an exhibit stating the
date of the dissolution and that all further filings with respect to
transactions in the security reported on will be filed, if required, by members
of the group, in their individual capacity. See Item 5.

          Not Applicable
          ----------------------------------------------------------------------

Item 10.  Certifications.

          By signing below I certify that, to the best of my knowledge and
          belief, the securities referred to above were not acquired and are not
          held for the purpose of or with the effect of changing or influencing
          the control of the issuer of the securities and were not acquired and
          are not held in connection with or as a participant in any transaction
          having such purpose or effect.


                                    SIGNATURE

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                        February 9, 2006
                                        ----------------------------------------
                                                        (Date)

                                        /s/ A. Alex Porter**
                                        ----------------------------------------
                                                      (Signature)

                                        A. Alex Porter
                                        ----------------------------------------
                                                      (Name/Title)

                                        /s/ Paul Orlin**
                                        ----------------------------------------
                                                      (Signature)

                                        Paul Orlin
                                        ----------------------------------------
                                                      (Name/Title)

                                        /s/ Geoffrey Hulme**
                                        ----------------------------------------
                                                      (Signature)

                                        Geoffrey Hulme
                                        ----------------------------------------
                                                      (Name/Title)

                                        /s/ Jonathan W. Friedland**
                                        ----------------------------------------
                                                      (Signature)

                                        Jonathan W. Friedland
                                        ----------------------------------------
                                                      (Name/Title)

** The reporting persons hereby disclaim beneficial ownership over the shares
reported herein except to the extent of their pecuniary interest therein.

Note. Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
for whom copies are to be sent.

Attention. Intentional misstatements or omissions of fact constitute federal
criminal violations (see 18 U.S.C. 1001).



Exhibit 1
                             Joint Filing Statement

                     Statement Pursuant to Rule 13d-1(k)(1)

     The undersigned hereby consent and agree to file a joint statement on
Schedule 13G under the Securities Exchange Act of 1934, as amended, with respect
to shares of common stock of Highland Hospitality Corporation beneficially owned
by them, together with any or all amendments thereto, when and if appropriate.
The parties hereto further consent and agree to file this Statement Pursuant to
Rule 13d-1(k)(1)(iii) as an exhibit to Schedule 13G, thereby incorporating the
same into such Schedule 13G.

Dated:  February 9, 2006                       /s/ A. Alex Porter
                                               ---------------------------------
                                               A. Alex Porter

Dated:  February 9, 2006                       /s/ Paul Orlin
                                               ---------------------------------
                                               Paul Orlin

Dated:  February 9, 2006                       /s/ Geoffrey Hulme
                                               ---------------------------------
                                               Geoffrey Hulme

Dated:  February 9, 2006                       /s/ Jonathan W. Friedland
                                               ---------------------------------
                                               Jonathan W. Friedland

SK 02903 0001 642279