UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (Amendment No.)*

                         SPECTRUM PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    84763A108
                                    ---------
                                 (CUSIP Number)

                                February 1, 2007
                                ----------------
                      (Date of Event which Requires Filing
                               of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

             [ ]    Rule 13d-1(b)
             [X]    Rule 13d-1(c)
             [ ]    Rule 13d-1(d)



*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


                                  Page 1 of 8





-------------------                                           -----------------
CUSIP No. 84763A108                   13G                     Page 2 of 8 Pages
-------------------                                           -----------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           CR Intrinsic Investors, LLC
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]
                                                                      (b) [X]

---------- ---------------------------------------------------------------------
3          SEC USE ONLY

---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
NUMBER OF            ------ ----------------------------------------------------
SHARES               6      SHARED VOTING POWER
BENEFICIALLY
OWNED                       500,000  (see Item 4)
BY                   ------ ----------------------------------------------------
EACH                 7      SOLE DISPOSITIVE POWER
REPORTING
PERSON                      0
WITH                 ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            500,000 (see Item 4)
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           500,000 (see Item 4)
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           2.0% (see Item 4)
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 2 of 8





-------------------                                           -----------------
CUSIP No. 84763A108                   13G                     Page 3 of 8 Pages
-------------------                                           -----------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Sigma Capital Management, LLC
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]
                                                                      (b) [X]

---------- ---------------------------------------------------------------------
3          SEC USE ONLY

---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
NUMBER OF            ------ ----------------------------------------------------
SHARES               6      SHARED VOTING POWER
BENEFICIALLY
OWNED                       775,000  (see Item 4)
BY                   ------ ----------------------------------------------------
EACH                 7      SOLE DISPOSITIVE POWER
REPORTING
PERSON                      0
WITH                 ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            775,000 (see Item 4)
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           775,000 (see Item 4)
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           3.1% (see Item 4)
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           00
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 3 of 8





-------------------                                           -----------------
CUSIP No. 84763A108                   13G                     Page 4 of 8 Pages
-------------------                                           -----------------

---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Steven A. Cohen
---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                      (a) [ ]
                                                                      (b) [X]

---------- ---------------------------------------------------------------------
3          SEC USE ONLY

---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
-------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
NUMBER OF            ------ ----------------------------------------------------
SHARES               6      SHARED VOTING POWER
BENEFICIALLY
OWNED                       1,275,000  (see Item 4)
BY                   ------ ----------------------------------------------------
EACH                 7      SOLE DISPOSITIVE POWER
REPORTING
PERSON                      0
WITH                 ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            1,275,000 (see Item 4)
---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,275,000 (see Item 4)
---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES

           [ ]
---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

           5.1% (see Item 4)
---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON*

           IN
---------- ---------------------------------------------------------------------
                       *SEE INSTRUCTION BEFORE FILLING OUT


                                  Page 4 of 8





Item 1(a)           Name of Issuer:
                    --------------

                    Spectrum Pharmaceuticals, Inc.

Item 1(b)           Address of Issuer's Principal Executive Offices:
                    -----------------------------------------------

                    157 Technology Drive, Irvine California 92618

Items 2(a)          Name of Person Filing:
                    ---------------------

                    This statement is filed by: (i) CR Intrinsic Investors, LLC
                    ("CR Intrinsic Investors") with respect to shares of common
                    stock ("Shares"), of the Issuer beneficially owned by CR
                    Intrinsic Investments, LLC ("CR Intrinsic Investments");
                    (ii) Sigma Capital Management, LLC ("Sigma Management") with
                    respect to Shares beneficially owned by Sigma Capital
                    Associates, LLC ("Sigma Capital Associates") and (iii)
                    Steven A. Cohen with respect to Shares beneficially owned by
                    CR Intrinsic Investors, CR Intrinsic Investments, Sigma
                    Management and Sigma Capital Associates.

                    CR Intrinsic Investors, Sigma Management and Steven A. Cohen
                    have entered into a Joint Filing Agreement, a copy of which
                    is filed with this Schedule 13G as Exhibit 99.1, pursuant to
                    which they have agreed to file this Schedule 13G jointly in
                    accordance with the provisions of Rule 13d-1(k) of the
                    Securities Exchange Act of 1934, as amended.

Item 2(b)           Address of Principal Business Office:
                    ------------------------------------

                    The address of the principal business office of (i) CR
                    Intrinsic Investors and Mr. Cohen is 72 Cummings Point Road,
                    Stamford, Connecticut 06902 and (ii) Sigma Management is 540
                    Madison Avenue, New York, New York 10022.

Item 2(c)           Citizenship:
                    -----------

                    CR Intrinsic Investors and Sigma Management are Delaware
                    limited liability companies. Mr. Cohen is a United States
                    citizen.

Item 2(d)           Title of Class of Securities:
                    ----------------------------

                    Common Stock

Item 2(e)           CUSIP Number:
                    ------------

                    84763A108

Item 3              Not Applicable


                                  Page 5 of 8





Item 4              Ownership:
                    ---------

                    The percentages used herein are calculated based upon the
                    Shares issued and outstanding as reported on the Issuer's
                    prospectus on Form 424B5 filed on December 6, 2006.

                    As of the close of business on February 1, 2007:

                    1. CR Intrinsic Investors, LLC
                    (a) Amount beneficially owned: 500,000
                    (b) Percent of class: 2.0%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 500,000
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    500,000

                    2. Sigma Capital Management, LLC
                    (a) Amount beneficially owned: 775,000
                    (b) Percent of class: 3.1%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 775,000
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    775,000

                    3. Steven A. Cohen
                    (a) Amount beneficially owned: 1,275,000
                    (b) Percent of class: 5.1%
                    (c)(i) Sole power to vote or direct the vote: -0-
                    (ii) Shared power to vote or direct the vote: 1,275,000
                    (iii) Sole power to dispose or direct the disposition: -0-
                    (iv) Shared power to dispose or direct the disposition:
                    1,275,000

                    CR Intrinsic Investors, Sigma Management and Mr. Cohen do
                    not directly own any Shares. Pursuant to an investment
                    management agreement, CR Intrinsic Investors maintains
                    investment and voting power with respect to the securities
                    held by CR Intrinsic Investments. Pursuant to an investment
                    management agreement, Sigma Management maintains investment
                    and voting power with respect to the securities held by
                    Sigma Capital Associates. Mr. Cohen controls each of CR
                    Intrinsic Investors and Sigma Management. By reason of the
                    provisions of Rule 13d-3 of the Securities Exchange Act of
                    1934, as amended, each of (i) CR Intrinsic Investors and Mr.
                    Cohen may be deemed to own beneficially 500,000 Shares
                    (constituting approximately 2.0% Shares outstanding) and
                    (ii) Sigma Management and Mr. Cohen may be deemed to own
                    beneficially 775,000 Shares (constituting approximately 3.1%
                    Shares outstanding). Each of CR Intrinsic Investors, Sigma
                    Management and Mr. Cohen disclaim beneficial


                                  Page 6 of 8





                    ownership of any of the securities covered by this
                    statement.

Item 5              Ownership of Five Percent or Less of a Class:
                    --------------------------------------------

                    If this statement is being filed to report the fact that as
                    of the date hereof the reporting person has ceased to be the
                    beneficial owner of more than five percent of the class of
                    securities, check the following.

Item 6              Ownership of More than Five Percent on Behalf of Another
                    --------------------------------------------------------
                    Person:
                    ------

                    Not Applicable

Item 7              Identification and Classification of the
                    ----------------------------------------
                    Subsidiary Which Acquired the Security Being
                    --------------------------------------------
                    Reported on By the Parent Holding Company:
                    -----------------------------------------

                    Not Applicable

Item 8              Identification and Classification of Members
                    --------------------------------------------
                    of the Group:
                    ------------

                    Not Applicable

Item 9              Notice of Dissolution of Group:
                    ------------------------------

                    Not Applicable

Item 10             Certification:
                    -------------

     By signing below the signatory certifies that, to the best of his knowledge
and belief, the securities referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing the control of
the issuer of the securities and were not acquired and are not held in
connection with or as a participant in any transaction having that purpose or
effect.


                                  Page 7 of 8





                                    SIGNATURE
                                    ---------

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:  February 5, 2007


CR INTRINSIC INVESTORS, LLC


By: /s/ Peter Nussbaum
   ---------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


SIGMA CAPITAL MANAGEMENT, LLC


By: /s/ Peter Nussbaum
   ---------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


STEVEN A. COHEN


By: /s/ Peter Nussbaum
   ---------------------------
Name:   Peter Nussbaum
Title:  Authorized Person


                                  Page 8 of 8