UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F COVER PAGE Report for the Calendar Year or Quarter Ended: March 31, 2012 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name:GENERAL AMERICAN INVESTORS COMPANY, INC. Address: 100 PARK AVE 35TH FLOOR NEW YORK, NY 10017 13F File Number: 28-461 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Eugene S. Stark Title: Vice-President, Administration Phone: 212-916-8447 Signature, Place, and Date of Signing: Eugene S. Stark New York, NY April 27, 2012 Report Type (Check only one.): [X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. List of Other Managers Reporting for this Manager: Form 13F File Number Name I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 54 Form 13F Information Table Value Total: $1006840184 List of Other Included Managers: No. 13F File Number Name VALUE SHARES/ SH/ PUT/ INVSTMT -----VOTING AUTHORITY----- NAME OF ISSUER TITLE OF CLASS CUSIP x$1000 PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE ---------------- -------------- ----- ------ ------------------------ -------- ---- ------ ---- ------- Apple Inc. COMMON 037833100 29978 50000 SH SOLE 50000 0 0 ABB Ltd. ADR COMMON 000375204 24492 1200000 SH SOLE 1200000 0 0 Arch Capital Group Ltd. COMMON G0450A105 32585 875000 SH SOLE 875000 0 0 Adams Express Company COMMON 006212104 1538 140091 SH SOLE 140091 0 0 Alpha Natural Resources, Inc. COMMON 02076X102 7114 467700 SH SOLE 467700 0 0 Aon Corporation COMMON 037389103 16214 330492 SH SOLE 330492 0 0 Apache Corporation COMMON 037411105 29778 296478 SH SOLE 296478 0 0 ASML Holding N.V. COMMON N07059186 28831 575000 SH SOLE 575000 0 0 American Express Company COMMON 025816109 18226 315000 SH SOLE 315000 0 0 Berkshire Hathaway Inc. Class A COMMON 084670108 13409 110 SH SOLE 110 0 0 Celgene Corporation COMMON 151020104 11628 150000 SH SOLE 150000 0 0 Central Securities Corporation COMMON 155123102 843 38102 SH SOLE 38102 0 0 Canadian Natural Resources COMMON 136385101 9954 300000 SH SOLE 300000 0 0 Costco Wholesale Corporation COMMON 22160K105 35821 394500 SH SOLE 394500 0 0 Cisco Systems, Inc. COMMON 17275R102 20304 960000 SH SOLE 960000 0 0 Cytokinetics, Incorporated COMMON 23282W100 609 529900 SH SOLE 529900 0 0 Dell Inc. COMMON 24702R101 13691 825000 SH SOLE 825000 0 0 Diageo plc ADR COMMON 25243Q205 33775 350000 SH SOLE 350000 0 0 Devon Energy Corporation COMMON 25179M103 9250 130062 SH SOLE 130062 0 0 Epoch Holding Corporation COMMON 29428R103 39800 1666667 SH SOLE 1666667 0 0 Ford Motor Company COMMON 345370860 15769 1264063 SH SOLE 1264063 0 0 Freeport-McMoRan COMMON 35671D857 7608 200000 SH SOLE 200000 0 0 Georgia Gulf Corporation COMMON 373200302 3540 101501 SH SOLE 101501 0 0 Gilead Sciences, Inc. COMMON 375558103 10471 214300 SH SOLE 214300 0 0 Halliburton Company COMMON 406216101 24893 750000 SH SOLE 750000 0 0 Idenix Pharmaceuticals, Inc. COMMON 45166R204 532 54306 SH SOLE 54306 0 0 International Game Technology COMMON 459902102 12593 750000 SH SOLE 750000 0 0 JPMorgan Chase & Co. COMMON 46625H100 23910 520000 SH SOLE 520000 0 0 JPMorgan Chase & Co. COMMON 46634E114 3011 225000 SH SOLE 225000 0 0 Kohl's Corporation COMMON 500255104 11104 221950 SH SOLE 221950 0 0 MetLife, Inc. COMMON 59156R108 12139 325000 SH SOLE 325000 0 0 Microsoft Corporation COMMON 594918104 24836 770000 SH SOLE 770000 0 0 M&T Bank Corporation COMMON 55261F104 9557 110000 SH SOLE 110000 0 0 The Manitowoc Company, Inc. COMMON 563571108 12474 900000 SH SOLE 900000 0 0 Nelnet, Inc. COMMON 64031N108 16712 645000 SH SOLE 645000 0 0 Nucor Corporation COMMON 670346105 6443 150000 SH SOLE 150000 0 0 PepsiCo, Inc. COMMON 713448108 21564 325000 SH SOLE 325000 0 0 Pfizer Inc. COMMON 717081103 17115 755808 SH SOLE 755808 0 0 PartnerRe Ltd. COMMON G6852T105 19349 285000 SH SOLE 285000 0 0 Platinum Underwriters COMMON G7127P100 15878 435000 SH SOLE 435000 0 0 QUALCOMM Incorporated COMMON 747525103 47642 700000 SH SOLE 700000 0 0 Everest Re Group, Ltd. COMMON G3223R108 22667 245000 SH SOLE 245000 0 0 Republic Services, Inc. COMMON 760759100 29249 957100 SH SOLE 957100 0 0 Royce Value Trust, Inc. COMMON 780910105 2170 156222 SH SOLE 156222 0 0 Teradata Corporation COMMON 88076W103 15675 230000 SH SOLE 230000 0 0 Target Corporation COMMON 87612E106 26804 460000 SH SOLE 460000 0 0 The TJX Companies, Inc. COMMON 872540109 85008 2140708 SH SOLE 2140708 0 0 Towers Watson & Co. Class A COMMON 891894107 13610 206000 SH SOLE 206000 0 0 United Technologies Corporation COMMON 913017109 26956 325000 SH SOLE 325000 0 0 Visteon Corporation COMMON 92839U206 14613 275713 SH SOLE 275713 0 0 Vodafone Group Plc ADR COMMON 92857W209 10462 378100 SH SOLE 378100 0 0 Weatherford International Ltd. COMMON G95089101 30935 2050000 SH SOLE 2050000 0 0 Waste Management, Inc. COMMON 94106L109 22025 630000 SH SOLE 630000 0 0 Wal-Mart Stores, Inc. COMMON 931142103 11692 191050 SH SOLE 191050 0 0