UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F COVER PAGE Report for the Calendar Year or Quarter Ended: March 31, 2011 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name:GENERAL AMERICAN INVESTORS COMPANY, INC. Address: 100 PARK AVE 35TH FLOOR NEW YORK, NY 10017 13F File Number: 28-461 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Eugene S. Stark Title: Vice-President, Administration Phone: 212-916-8447 Signature, Place, and Date of Signing: Eugene S. Stark New York, NY May 02, 2011 Report Type (Check only one.): [X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. List of Other Managers Reporting for this Manager: Form 13F File Number Name I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 61 Form 13F Information Table Value Total: $1088395450 List of Other Included Managers: No. 13F File Number Name VALUE SHARES/ SH/ PUT/ INVSTMT -----VOTING AUTHORITY----- NAME OF ISSUER TITLE OF CLASS CUSIP x$1000 PRN AMT PRN CALL DSCRETN -MANAGERS- SOLE SHARED NONE -------------- -------------- ----- ------ ---------------- ------- ---------- ----------------------- Apple Inc. COMMON 037833100 20910 60000 SH SOLE 60000 0 0 ABB Ltd. ADR COMMON 000375204 29028 1200000 SH SOLE 1200000 0 0 Arch Capital Group Ltd. COMMON G0450A105 31245 315000 SH SOLE 315000 0 0 Adams Express Company COMMON 006212104 1515 133254 SH SOLE 133254 0 0 Amgen Inc. COMMON 031162100 2138 40000 SH SOLE 40000 0 0 Alpha Natural Resources, Inc. COMMON 02076X102 13311 224200 SH SOLE 224200 0 0 Aon Corporation COMMON 037389103 17503 330492 SH SOLE 330492 0 0 Apache Corporation COMMON 037411105 38815 296478 SH SOLE 296478 0 0 ASML Holding N.V. COMMON N07059186 25588 575000 SH SOLE 575000 0 0 American Express Company COMMON 025816109 16950 375000 SH SOLE 375000 0 0 Berkshire Hathaway Inc. Class A COMMON 084670108 13783 110 SH SOLE 110 0 0 Celgene Corporation COMMON 151020104 11515 200000 SH SOLE 200000 0 0 Cephalon, Inc. COMMON 156708109 19941 262100 SH SOLE 262100 0 0 Central Securities Corporation COMMON 155123102 860 36686 SH SOLE 36686 0 0 Canadian Natural Resources COMMON 136385101 14829 300000 SH SOLE 300000 0 0 Costco Wholesale Corporation COMMON 22160K105 42159 575000 SH SOLE 575000 0 0 Cisco Systems, Inc. COMMON 17275R102 16464 960000 SH SOLE 960000 0 0 CEMEX, S.A. de C.V. ADR COMMON 151290889 16224 1816755 SH SOLE 1816755 0 0 Cytokinetics, Incorporated COMMON 23282W100 790 529900 SH SOLE 529900 0 0 Dell Inc. COMMON 24702R101 14728 1015000 SH SOLE 1015000 0 0 Diageo plc ADR COMMON 25243Q205 26677 350000 SH SOLE 350000 0 0 Devon Energy Corporation COMMON 25179M103 11936 130062 SH SOLE 130062 0 0 Epoch Holding Corporation COMMON 29428R103 26300 1666667 SH SOLE 1666667 0 0 Freeport-McMoRan COMMON 35671D857 11110 200000 SH SOLE 200000 0 0 Fidelity National Financial, Inc COMMON 31620R105 7418 525000 SH SOLE 525000 0 0 Gilead Sciences, Inc. COMMON 375558103 23974 564500 SH SOLE 564500 0 0 Halliburton Company COMMON 406216101 36134 725000 SH SOLE 725000 0 0 International Game Technology COMMON 459902102 12173 750000 SH SOLE 750000 0 0 J.C. Penney Company, Inc. COMMON 708160106 14364 400000 SH SOLE 400000 0 0 JPMorgan Chase & Co. COMMON 46625H100 19593 425000 SH SOLE 425000 0 0 JPMorgan Chase & Co. COMMON 46634E114 2937 175000 SH SOLE 175000 0 0 Massey Energy Company COMMON 576206106 6836 100000 SH SOLE 100000 0 0 MetLife, Inc. COMMON 59156R108 14537 325000 SH SOLE 325000 0 0 MSCI Inc. Class A COMMON 55354G100 11046 300000 SH SOLE 300000 0 0 Microsoft Corporation COMMON 594918104 19550 770000 SH SOLE 770000 0 0 M&T Bank Corporation COMMON 55261F104 9732 110000 SH SOLE 110000 0 0 The Manitowoc Company, Inc. COMMON 563571108 19692 900000 SH SOLE 900000 0 0 Nelnet, Inc. COMMON 64031N108 12880 590000 SH SOLE 590000 0 0 Nucor Corporation COMMON 670346105 6903 150000 SH SOLE 150000 0 0 Poniard Pharmaceuticals, Inc. COMMON 732449301 82 195344 SH SOLE 195344 0 0 PepsiCo, Inc. COMMON 713448108 20933 325000 SH SOLE 325000 0 0 Pfizer Inc. COMMON 717081103 15350 755808 SH SOLE 755808 0 0 PartnerRe Ltd. COMMON G6852T105 20602 260000 SH SOLE 260000 0 0 Platinum Underwriters COMMON G7127P100 571 15000 SH SOLE 15000 0 0 QUALCOMM Incorporated COMMON 747525103 38381 700000 SH SOLE 700000 0 0 Everest Re Group, Ltd. COMMON G3223R108 21604 245000 SH SOLE 245000 0 0 Republic Services, Inc. COMMON 760759100 28751 957100 SH SOLE 957100 0 0 Royce Value Trust, Inc. COMMON 780910105 2263 147038 SH SOLE 147038 0 0 Smurfit-Stone Container COMMON 83272A104 9601 248421 SH SOLE 248421 0 0 Teradata Corporation COMMON 88076W103 18252 360000 SH SOLE 360000 0 0 Target Corporation COMMON 87612E106 16553 331000 SH SOLE 331000 0 0 The TJX Companies, Inc. COMMON 872540109 75212 1512400 SH SOLE 1512400 0 0 Transatlantic Holdings, Inc. COMMON 893521104 4040 83000 SH SOLE 83000 0 0 The Travelers Companies, Inc. COMMON 89417E109 11896 200000 SH SOLE 200000 0 0 Towers Watson & Co. Class A COMMON 891894107 11425 206000 SH SOLE 206000 0 0 United Technologies Corporation COMMON 913017109 27511 325000 SH SOLE 325000 0 0 Visteon Corporation COMMON 92839U206 15860 253813 SH SOLE 253813 0 0 Weatherford International Ltd. COMMON G95089101 46330 2050000 SH SOLE 2050000 0 0 Waste Management, Inc. COMMON 94106L109 23524 630000 SH SOLE 630000 0 0 Wal-Mart Stores, Inc. COMMON 931142103 17333 333000 SH SOLE 333000 0 0 Xerox Corporation COMMON 984121103 20235 1900000 SH SOLE 1900000 0 0