UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   FORM 13F

                             FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: March 31, 2011

Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
                                  [ ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:GENERAL AMERICAN INVESTORS COMPANY, INC.
Address: 100 PARK AVE 35TH FLOOR
         NEW YORK, NY 10017

13F File Number: 28-461

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:

Name: Eugene S. Stark
Title: Vice-President, Administration
Phone: 212-916-8447
Signature, Place, and Date of Signing:

  Eugene S. Stark   New York, NY   May 02, 2011


Report Type (Check only one.):

[X]    13F HOLDINGS REPORT.

[ ]    13F NOTICE.

[ ]    13F COMBINATION REPORT.


List of Other Managers Reporting for this Manager:

        Form 13F File Number                Name


I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934.


FORM 13F SUMMARY PAGE


Report Summary:

Number of Other Included Managers:       0

Form 13F Information Table Entry Total:  61

Form 13F Information Table Value Total:  $1088395450



List of Other Included Managers:

No.   13F File Number    Name




                                                              VALUE   SHARES/ SH/ PUT/ INVSTMT            -----VOTING AUTHORITY-----
NAME OF ISSUER                 TITLE OF CLASS     CUSIP       x$1000  PRN AMT PRN CALL DSCRETN -MANAGERS-     SOLE   SHARED     NONE
--------------                 --------------     -----         ------  ---------------- ------- ----------  -----------------------
                                                                                                   
Apple Inc.                       COMMON           037833100    20910    60000 SH       SOLE                  60000        0     0
ABB Ltd. ADR                     COMMON           000375204    29028  1200000 SH       SOLE                1200000        0     0
Arch Capital Group Ltd.          COMMON           G0450A105    31245   315000 SH       SOLE                 315000        0     0
Adams Express Company            COMMON           006212104     1515   133254 SH       SOLE                 133254        0     0
Amgen Inc.                       COMMON           031162100     2138    40000 SH       SOLE                  40000        0     0
Alpha Natural Resources, Inc.    COMMON           02076X102    13311   224200 SH       SOLE                 224200        0     0
Aon Corporation                  COMMON           037389103    17503   330492 SH       SOLE                 330492        0     0
Apache Corporation               COMMON           037411105    38815   296478 SH       SOLE                 296478        0     0
ASML Holding N.V.                COMMON           N07059186    25588   575000 SH       SOLE                 575000        0     0
American Express Company         COMMON           025816109    16950   375000 SH       SOLE                 375000        0     0
Berkshire Hathaway Inc. Class A  COMMON           084670108    13783      110 SH       SOLE                    110        0     0
Celgene Corporation              COMMON           151020104    11515   200000 SH       SOLE                 200000        0     0
Cephalon, Inc.                   COMMON           156708109    19941   262100 SH       SOLE                 262100        0     0
Central Securities Corporation   COMMON           155123102      860    36686 SH       SOLE                  36686        0     0
Canadian Natural Resources       COMMON           136385101    14829   300000 SH       SOLE                 300000        0     0
Costco Wholesale Corporation     COMMON           22160K105    42159   575000 SH       SOLE                 575000        0     0
Cisco Systems, Inc.              COMMON           17275R102    16464   960000 SH       SOLE                 960000        0     0
CEMEX, S.A. de C.V. ADR          COMMON           151290889    16224  1816755 SH       SOLE                1816755        0     0
Cytokinetics, Incorporated       COMMON           23282W100      790   529900 SH       SOLE                 529900        0     0
Dell Inc.                        COMMON           24702R101    14728  1015000 SH       SOLE                1015000        0     0
Diageo plc ADR                   COMMON           25243Q205    26677   350000 SH       SOLE                 350000        0     0
Devon Energy Corporation         COMMON           25179M103    11936   130062 SH       SOLE                 130062        0     0
Epoch Holding Corporation        COMMON           29428R103    26300  1666667 SH       SOLE                1666667        0     0
Freeport-McMoRan                 COMMON           35671D857    11110   200000 SH       SOLE                 200000        0     0
Fidelity National Financial, Inc COMMON           31620R105     7418   525000 SH       SOLE                 525000        0     0
Gilead Sciences, Inc.            COMMON           375558103    23974   564500 SH       SOLE                 564500        0     0
Halliburton Company              COMMON           406216101    36134   725000 SH       SOLE                 725000        0     0
International Game Technology    COMMON           459902102    12173   750000 SH       SOLE                 750000        0     0
J.C. Penney Company, Inc.        COMMON           708160106    14364   400000 SH       SOLE                 400000        0     0
JPMorgan Chase & Co.             COMMON           46625H100    19593   425000 SH       SOLE                 425000        0     0
JPMorgan Chase & Co.             COMMON           46634E114     2937   175000 SH       SOLE                 175000        0     0
Massey Energy Company            COMMON           576206106     6836   100000 SH       SOLE                 100000        0     0
MetLife, Inc.                    COMMON           59156R108    14537   325000 SH       SOLE                 325000        0     0
MSCI Inc. Class A                COMMON           55354G100    11046   300000 SH       SOLE                 300000        0     0
Microsoft Corporation            COMMON           594918104    19550   770000 SH       SOLE                 770000        0     0
M&T Bank Corporation             COMMON           55261F104     9732   110000 SH       SOLE                 110000        0     0
The Manitowoc Company, Inc.      COMMON           563571108    19692   900000 SH       SOLE                 900000        0     0
Nelnet, Inc.                     COMMON           64031N108    12880   590000 SH       SOLE                 590000        0     0
Nucor Corporation                COMMON           670346105     6903   150000 SH       SOLE                 150000        0     0
Poniard Pharmaceuticals, Inc.    COMMON           732449301       82   195344 SH       SOLE                 195344        0     0
PepsiCo, Inc.                    COMMON           713448108    20933   325000 SH       SOLE                 325000        0     0
Pfizer Inc.                      COMMON           717081103    15350   755808 SH       SOLE                 755808        0     0
PartnerRe Ltd.                   COMMON           G6852T105    20602   260000 SH       SOLE                 260000        0     0
Platinum Underwriters            COMMON           G7127P100      571    15000 SH       SOLE                  15000        0     0
QUALCOMM Incorporated            COMMON           747525103    38381   700000 SH       SOLE                 700000        0     0
Everest Re Group, Ltd.           COMMON           G3223R108    21604   245000 SH       SOLE                 245000        0     0
Republic Services, Inc.          COMMON           760759100    28751   957100 SH       SOLE                 957100        0     0
Royce Value Trust, Inc.          COMMON           780910105     2263   147038 SH       SOLE                 147038        0     0
Smurfit-Stone Container          COMMON           83272A104     9601   248421 SH       SOLE                 248421        0     0
Teradata Corporation             COMMON           88076W103    18252   360000 SH       SOLE                 360000        0     0
Target Corporation               COMMON           87612E106    16553   331000 SH       SOLE                 331000        0     0
The TJX Companies, Inc.          COMMON           872540109    75212  1512400 SH       SOLE                1512400        0     0
Transatlantic Holdings, Inc.     COMMON           893521104     4040    83000 SH       SOLE                  83000        0     0
The Travelers Companies, Inc.    COMMON           89417E109    11896   200000 SH       SOLE                 200000        0     0
Towers Watson & Co. Class A      COMMON           891894107    11425   206000 SH       SOLE                 206000        0     0
United Technologies Corporation  COMMON           913017109    27511   325000 SH       SOLE                 325000        0     0
Visteon Corporation              COMMON           92839U206    15860   253813 SH       SOLE                 253813        0     0
Weatherford International Ltd.   COMMON           G95089101    46330  2050000 SH       SOLE                2050000        0     0
Waste Management, Inc.           COMMON           94106L109    23524   630000 SH       SOLE                 630000        0     0
Wal-Mart Stores, Inc.            COMMON           931142103    17333   333000 SH       SOLE                 333000        0     0
Xerox Corporation                COMMON           984121103    20235  1900000 SH       SOLE                1900000        0     0