UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                   FORM 13F

                             FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: December 31, 2010

Check here if Amendment [ ]; Amendment Number:
This Amendment (Check only one.): [ ] is a restatement.
                                  [ ] adds new holdings entries.

Institutional Investment Manager Filing this Report:

Name:GENERAL AMERICAN INVESTORS COMPANY, INC.
Address: 100 PARK AVE 35TH FLOOR
         NEW YORK, NY 10017

13F File Number: 28-461

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.


Person Signing this Report on Behalf of Reporting Manager:

Name: Eugene S. Stark
Title: Vice-President, Administration
Phone: 212-916-8447
Signature, Place, and Date of Signing:

  Eugene S. Stark   New York, NY   February 04, 2011


Report Type (Check only one.):

[X]    13F HOLDINGS REPORT.

[ ]    13F NOTICE.

[ ]    13F COMBINATION REPORT.


List of Other Managers Reporting for this Manager:

        Form 13F File Number                Name


I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934.

FORM 13F SUMMARY PAGE


Report Summary:

Number of Other Included Managers:       0

Form 13F Information Table Entry Total:  58

Form 13F Information Table Value Total:  $1025825845



List of Other Included Managers:

No.   13F File Number    Name




                                                             VALUE    SHARES/ SH/ PUT/ INVSTMT   OTHER       --VOTING AUTHORITY--
  NAME OF ISSUER                 TITLE OF CLASS   CUSIP     (x$1000)  PRN AMT PRN CALL DSCRETN  MANAGERS     SOLE   SHARED   NONE
-------------------------------  --------------   -----      -------  ------- --- ---- -------  --------   -------  -------  ----
                                                                                                    
Apple Inc.                       COMMON           037833100    19354    60000 SH       SOLE                  60000        0      0
ABB Ltd. ADR                     COMMON           000375204    26940  1200000 SH       SOLE                1200000        0      0
Arch Capital Group Ltd.          COMMON           G0450A105    27736   315000 SH       SOLE                 315000        0      0
Adams Express Company            COMMON           006212104     1431   133255 SH       SOLE                 133255        0      0
Alexander & Baldwin, Inc.        COMMON           014482103     7596   189762 SH       SOLE                 189762        0      0
Amgen Inc.                       COMMON           031162100     2196    40000 SH       SOLE                  40000        0      0
Alpha Natural Resources, Inc.    COMMON           02076X102    13459   224200 SH       SOLE                 224200        0      0
Aon Corporation                  COMMON           037389103    15206   330492 SH       SOLE                 330492        0      0
Apache Corporation               COMMON           037411105    35349   296478 SH       SOLE                 296478        0      0
ASML Holding N.V.                COMMON           N07059186    22046   575000 SH       SOLE                 575000        0      0
American Express Company         COMMON           025816109    16095   375000 SH       SOLE                 375000        0      0
Berkshire Hathaway Inc. Class A  COMMON           084670108    13250      110 SH       SOLE                    110        0      0
Celgene Corporation              COMMON           151020104    11828   200000 SH       SOLE                 200000        0      0
Cephalon, Inc.                   COMMON           156708109    23583   382100 SH       SOLE                 382100        0      0
Central Securities Corporation   COMMON           155123102      806    36686 SH       SOLE                  36686        0      0
Canadian Natural Resources       COMMON           136385101    11105   250000 SH       SOLE                 250000        0      0
Costco Wholesale Corporation     COMMON           22160K105    41521   575000 SH       SOLE                 575000        0      0
Cisco Systems, Inc.              COMMON           17275R102    19421   960000 SH       SOLE                 960000        0      0
CEMEX, S.A. de C.V. ADR          COMMON           151290889    20851  1946880 SH       SOLE                1946880        0      0
Cytokinetics, Incorporated       COMMON           23282W100     1107   529900 SH       SOLE                 529900        0      0
Dell Inc.                        COMMON           24702R101    13753  1015000 SH       SOLE                1015000        0      0
Diageo plc ADR                   COMMON           25243Q205    26016   350000 SH       SOLE                 350000        0      0
Devon Energy Corporation         COMMON           25179M103    10211   130062 SH       SOLE                 130062        0      0
Epoch Holding Corporation        COMMON           29428R103    25883  1666667 SH       SOLE                1666667        0      0
Freeport-McMoRan                 COMMON           35671D857    12009   100000 SH       SOLE                 100000        0      0
Fidelity National Financial, Inc COMMON           31620R105     9576   700000 SH       SOLE                 700000        0      0
Gilead Sciences, Inc.            COMMON           375558103    20457   564500 SH       SOLE                 564500        0      0
Halliburton Company              COMMON           406216101    31847   780000 SH       SOLE                 780000        0      0
International Game Technology    COMMON           459902102    13268   750000 SH       SOLE                 750000        0      0
J.C. Penney Company, Inc.        COMMON           708160106    12924   400000 SH       SOLE                 400000        0      0
JPMorgan Chase & Co.             COMMON           46625H100    18029   425000 SH       SOLE                 425000        0      0
JPMorgan Chase & Co.             COMMON           46634E114     2529   175000 SH       SOLE                 175000        0      0
MetLife, Inc.                    COMMON           59156R108    12221   275000 SH       SOLE                 275000        0      0
MSCI Inc. Class A                COMMON           55354G100    11688   300000 SH       SOLE                 300000        0      0
Microsoft Corporation            COMMON           594918104    21491   770000 SH       SOLE                 770000        0      0
M&T Bank Corporation             COMMON           55261F104     9576   110000 SH       SOLE                 110000        0      0
The Manitowoc Company, Inc.      COMMON           563571108    13110  1000000 SH       SOLE                1000000        0      0
Nelnet, Inc.                     COMMON           64031N108    13977   590000 SH       SOLE                 590000        0      0
NetEase.com, Inc.                COMMON           64110W102     6077   168100 SH       SOLE                 168100        0      0
Nucor Corporation                COMMON           670346105     6573   150000 SH       SOLE                 150000        0      0
Poniard Pharmaceuticals, Inc.    COMMON           732449301      102   195344 SH       SOLE                 195344        0      0
PepsiCo, Inc.                    COMMON           713448108    20579   315000 SH       SOLE                 315000        0      0
Pfizer Inc.                      COMMON           717081103    13234   755808 SH       SOLE                 755808        0      0
PartnerRe Ltd.                   COMMON           G6852T105    20891   260000 SH       SOLE                 260000        0      0
QUALCOMM Incorporated            COMMON           747525103    34643   700000 SH       SOLE                 700000        0      0
Everest Re Group, Ltd.           COMMON           G3223R108    20781   245000 SH       SOLE                 245000        0      0
Republic Services, Inc.          COMMON           760759100    28579   957100 SH       SOLE                 957100        0      0
Royce Value Trust, Inc.          COMMON           780910105     2112   145269 SH       SOLE                 145269        0      0
Teradata Corporation             COMMON           88076W103    14818   360000 SH       SOLE                 360000        0      0
The TJX Companies, Inc.          COMMON           872540109    72462  1632400 SH       SOLE                1632400        0      0
Transatlantic Holdings, Inc.     COMMON           893521104     4284    83000 SH       SOLE                  83000        0      0
The Travelers Companies, Inc.    COMMON           89417E109    11142   200000 SH       SOLE                 200000        0      0
Towers Watson & Co. Class A      COMMON           891894107    10724   206000 SH       SOLE                 206000        0      0
United Technologies Corporation  COMMON           913017109    25584   325000 SH       SOLE                 325000        0      0
Weatherford International Ltd.   COMMON           G95089101    49020  2150000 SH       SOLE                2150000        0      0
Waste Management, Inc.           COMMON           94106L109    23228   630000 SH       SOLE                 630000        0      0
Wal-Mart Stores, Inc.            COMMON           931142103    29662   550000 SH       SOLE                 550000        0      0
Xerox Corporation                COMMON           984121103    21888  1900000 SH       SOLE                1900000        0      0