UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F COVER PAGE Report for the Calendar Year or Quarter Ended: December 31, 2010 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name:GENERAL AMERICAN INVESTORS COMPANY, INC. Address: 100 PARK AVE 35TH FLOOR NEW YORK, NY 10017 13F File Number: 28-461 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Eugene S. Stark Title: Vice-President, Administration Phone: 212-916-8447 Signature, Place, and Date of Signing: Eugene S. Stark New York, NY February 04, 2011 Report Type (Check only one.): [X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. List of Other Managers Reporting for this Manager: Form 13F File Number Name I AM SIGNING THIS REPORT AS REQUIRED BY THE SECURITIES EXCHANGE ACT OF 1934. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 0 Form 13F Information Table Entry Total: 58 Form 13F Information Table Value Total: $1025825845 List of Other Included Managers: No. 13F File Number Name VALUE SHARES/ SH/ PUT/ INVSTMT OTHER --VOTING AUTHORITY-- NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE ------------------------------- -------------- ----- ------- ------- --- ---- ------- -------- ------- ------- ---- Apple Inc. COMMON 037833100 19354 60000 SH SOLE 60000 0 0 ABB Ltd. ADR COMMON 000375204 26940 1200000 SH SOLE 1200000 0 0 Arch Capital Group Ltd. COMMON G0450A105 27736 315000 SH SOLE 315000 0 0 Adams Express Company COMMON 006212104 1431 133255 SH SOLE 133255 0 0 Alexander & Baldwin, Inc. COMMON 014482103 7596 189762 SH SOLE 189762 0 0 Amgen Inc. COMMON 031162100 2196 40000 SH SOLE 40000 0 0 Alpha Natural Resources, Inc. COMMON 02076X102 13459 224200 SH SOLE 224200 0 0 Aon Corporation COMMON 037389103 15206 330492 SH SOLE 330492 0 0 Apache Corporation COMMON 037411105 35349 296478 SH SOLE 296478 0 0 ASML Holding N.V. COMMON N07059186 22046 575000 SH SOLE 575000 0 0 American Express Company COMMON 025816109 16095 375000 SH SOLE 375000 0 0 Berkshire Hathaway Inc. Class A COMMON 084670108 13250 110 SH SOLE 110 0 0 Celgene Corporation COMMON 151020104 11828 200000 SH SOLE 200000 0 0 Cephalon, Inc. COMMON 156708109 23583 382100 SH SOLE 382100 0 0 Central Securities Corporation COMMON 155123102 806 36686 SH SOLE 36686 0 0 Canadian Natural Resources COMMON 136385101 11105 250000 SH SOLE 250000 0 0 Costco Wholesale Corporation COMMON 22160K105 41521 575000 SH SOLE 575000 0 0 Cisco Systems, Inc. COMMON 17275R102 19421 960000 SH SOLE 960000 0 0 CEMEX, S.A. de C.V. ADR COMMON 151290889 20851 1946880 SH SOLE 1946880 0 0 Cytokinetics, Incorporated COMMON 23282W100 1107 529900 SH SOLE 529900 0 0 Dell Inc. COMMON 24702R101 13753 1015000 SH SOLE 1015000 0 0 Diageo plc ADR COMMON 25243Q205 26016 350000 SH SOLE 350000 0 0 Devon Energy Corporation COMMON 25179M103 10211 130062 SH SOLE 130062 0 0 Epoch Holding Corporation COMMON 29428R103 25883 1666667 SH SOLE 1666667 0 0 Freeport-McMoRan COMMON 35671D857 12009 100000 SH SOLE 100000 0 0 Fidelity National Financial, Inc COMMON 31620R105 9576 700000 SH SOLE 700000 0 0 Gilead Sciences, Inc. COMMON 375558103 20457 564500 SH SOLE 564500 0 0 Halliburton Company COMMON 406216101 31847 780000 SH SOLE 780000 0 0 International Game Technology COMMON 459902102 13268 750000 SH SOLE 750000 0 0 J.C. Penney Company, Inc. COMMON 708160106 12924 400000 SH SOLE 400000 0 0 JPMorgan Chase & Co. COMMON 46625H100 18029 425000 SH SOLE 425000 0 0 JPMorgan Chase & Co. COMMON 46634E114 2529 175000 SH SOLE 175000 0 0 MetLife, Inc. COMMON 59156R108 12221 275000 SH SOLE 275000 0 0 MSCI Inc. Class A COMMON 55354G100 11688 300000 SH SOLE 300000 0 0 Microsoft Corporation COMMON 594918104 21491 770000 SH SOLE 770000 0 0 M&T Bank Corporation COMMON 55261F104 9576 110000 SH SOLE 110000 0 0 The Manitowoc Company, Inc. COMMON 563571108 13110 1000000 SH SOLE 1000000 0 0 Nelnet, Inc. COMMON 64031N108 13977 590000 SH SOLE 590000 0 0 NetEase.com, Inc. COMMON 64110W102 6077 168100 SH SOLE 168100 0 0 Nucor Corporation COMMON 670346105 6573 150000 SH SOLE 150000 0 0 Poniard Pharmaceuticals, Inc. COMMON 732449301 102 195344 SH SOLE 195344 0 0 PepsiCo, Inc. COMMON 713448108 20579 315000 SH SOLE 315000 0 0 Pfizer Inc. COMMON 717081103 13234 755808 SH SOLE 755808 0 0 PartnerRe Ltd. COMMON G6852T105 20891 260000 SH SOLE 260000 0 0 QUALCOMM Incorporated COMMON 747525103 34643 700000 SH SOLE 700000 0 0 Everest Re Group, Ltd. COMMON G3223R108 20781 245000 SH SOLE 245000 0 0 Republic Services, Inc. COMMON 760759100 28579 957100 SH SOLE 957100 0 0 Royce Value Trust, Inc. COMMON 780910105 2112 145269 SH SOLE 145269 0 0 Teradata Corporation COMMON 88076W103 14818 360000 SH SOLE 360000 0 0 The TJX Companies, Inc. COMMON 872540109 72462 1632400 SH SOLE 1632400 0 0 Transatlantic Holdings, Inc. COMMON 893521104 4284 83000 SH SOLE 83000 0 0 The Travelers Companies, Inc. COMMON 89417E109 11142 200000 SH SOLE 200000 0 0 Towers Watson & Co. Class A COMMON 891894107 10724 206000 SH SOLE 206000 0 0 United Technologies Corporation COMMON 913017109 25584 325000 SH SOLE 325000 0 0 Weatherford International Ltd. COMMON G95089101 49020 2150000 SH SOLE 2150000 0 0 Waste Management, Inc. COMMON 94106L109 23228 630000 SH SOLE 630000 0 0 Wal-Mart Stores, Inc. COMMON 931142103 29662 550000 SH SOLE 550000 0 0 Xerox Corporation COMMON 984121103 21888 1900000 SH SOLE 1900000 0 0