Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
PESEC JOHN A
  2. Issuer Name and Ticker or Trading Symbol
KEITHLEY INSTRUMENTS INC [KEI]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP Worldwide Sales & Support
(Last)
(First)
(Middle)
KEITHLEY INSTRUMENTS, INC., 28775 AURORA ROAD
3. Date of Earliest Transaction (Month/Day/Year)
07/29/2008
(Street)

SOLON, OH 44139
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Shares 06/30/2008   J(1)   28 A $ 9.67 7,236 D  
Common Shares 07/29/2008   M   12,000 A $ 4.125 19,236 D  
Common Shares 07/29/2008   S   12,000 D $ 9.9992 (2) 7,236 D  
Common Shares               10 I Jointly held with wife
Common Shares               9 I Wife

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Common Share Option $ 4.125 07/29/2008   M     12,000 07/17/2001 07/16/2009 Common Shares 12,000 $ 0 0 D  
Common Share Option $ 45.125             08/02/2002(3) 08/01/2010 Common Shares 11,000   11,000 D  
Common Share Option $ 18.41             07/25/2003(3) 07/24/2011 Common Shares 25,000   25,000 D  
Common Share Option $ 13.76             07/24/2004(3) 07/23/2012 Common Shares 27,000   27,000 D  
Common Share Option $ 16.12             08/10/2005(4) 07/18/2013 Common Shares 30,000   30,000 D  
Common Share Option $ 18.75             02/15/2005(5) 07/16/2014 Common Shares 26,000   26,000 D  
Common Share Option $ 15.05             10/04/2007(3) 10/03/2015 Common Shares 10,000   10,000 D  
Performance Award Unit $ 0             09/30/2008(6)   (6) Common Shares 7,700 (6)   7,700 (6) D  
Common Share Option $ 14             01/30/2009(3) 01/30/2017 Common Shares 10,000   10,000 D  
Performance Award Unit $ 0             09/30/2009(6)   (6) Common Shares 7,700 (6)   7,700 (6) D  
Common Share Option $ 9.12             11/09/2009(3) 11/09/2017 Common Shares 7,500   7,500 D  
Performance Award Unit $ 0             09/30/2010(6)   (6) Common Shares 5,700 (6)   5,700 (6) D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
PESEC JOHN A
KEITHLEY INSTRUMENTS, INC.
28775 AURORA ROAD
SOLON, OH 44139
      VP Worldwide Sales & Support  

Signatures

 Mark J. Plush, Attorney-in Fact   07/30/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Acquired through Employee Stock Purchase and Dividend Reinvestment Plan.
(2) Average sales price of $9.9992 used (prices ranged from $9.91 to $10.08)
(3) Date reported applies to 50% of total, one-half of the balance is then exercisable in each succeeding year.
(4) Option became fully vested on August 10, 2005
(5) Option became fully vested on February 15, 2005
(6) Each Performance Award Unit represents the right to receive one common share. The number of units initially awarded, the target, is shown above. The actual number of units that will be awarded and converted to shares is based upon: a) the Company's revenue growth as compared to a defined Peer Group and, b) the Company maintaining an acceptable level of profitability during the performance period which ends on the date exercisable (the "vesting date"). Awarded units are automatically converted to shares under the Plan on or before the December 31st following the Vesting Date.

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