UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  ------------

                                    FORM 6-K

                                  ------------

                            REPORT OF FOREIGN ISSUER

                       Pursuant to Rule 13a-16 or 15d-16
                     of the Securities Exchange Act of 1934


                                November 3, 2008


                                  ------------

                                NOVO NORDISK A/S
             (Exact name of Registrant as specified in its charter)


                                    NOVO ALLE
                               DK-2880, BAGSVAERD
                                     DENMARK
                    (Address of principal executive offices)

                                  ------------

Indicate by check mark whether the registrant files or will file annual reports
under cover of Form 20-F or Form 40-F

                       Form 20-F [X]     Form 40-F [ ]


Indicate by check mark whether the registrant by furnishing the information
contained in this Form is also thereby furnishing the information to the
Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

                             Yes [ ]     No [X]


If "Yes" is marked, indicate below the file number assigned to the registrant in
connection with Rule 12g-32(b):82-_____________________







DIRECTOR/PDMR SHAREHOLDING

TRADING IN NOVO NORDISK SHARES BY BOARD MEMBERS, EXECUTIVES AND ASSOCIATED
PERSONS AS REPORTED TO NOVO NORDISK ON 30 OCTOBER 2008

In accordance with Section 28a of the Danish Securities Trading Act, Novo
Nordisk is required on a daily basis to publish trading in Novo Nordisk shares
by the company's board members, executives and their associated persons as
reported by those persons to Novo Nordisk.

Please find below a statement of such trading in shares issued by Novo Nordisk.

NAME                                    LARS REBIEN SORENSEN
REASON FOR REPORTING                    CHIEF EXECUTIVE OFFICER
FINANCIAL INSTRUMENT AND ID CODE        NOVO NORDISK B DK006010261
TYPE OF TRANSACTION                     EXERCISE OF OPTIONS (PURCHASE OF SHARES)
DATE OF TRANSACTION                     30 OCTOBER 2008
PLACE OF TRANSACTION                    NASDAQ OMX COPENHAGEN
VOLUME OF TRANSACTION                   1,000 SHARES
TOTAL VALUE OF TRANSACTION              DKK 97,500


NAME                                    LARS REBIEN SORENSEN
REASON FOR REPORTING                    CHIEF EXECUTIVE OFFICER
FINANCIAL INSTRUMENT AND ID CODE        NOVO NORDISK B DK006010261
TYPE OF TRANSACTION                     SALE OF SHARES
DATE OF TRANSACTION                     30 OCTOBER 2008
PLACE OF TRANSACTION                    NASDAQ OMX COPENHAGEN
VOLUME OF TRANSACTION                   1,000 SHARES
TOTAL VALUE OF TRANSACTION              DKK 307,500


NAME                                    JESPER BRANDGAARD
REASON FOR REPORTING                    CHIEF FINANCIAL OFFICER
FINANCIAL INSTRUMENT AND ID CODE        NOVO NORDISK B DK006010261
TYPE OF TRANSACTION                     EXERCISE OF OPTIONS (PURCHASE OF SHARES)
DATE OF TRANSACTION                     30 OCTOBER 2008
PLACE OF TRANSACTION                    NASDAQ OMX COPENHAGEN
VOLUME OF TRANSACTION                   1,000 SHARES
TOTAL VALUE OF TRANSACTION              DKK 97,500


NAME                                    JESPER BRANDGAARD
REASON FOR REPORTING                    CHIEF FINANCIAL OFFICER
FINANCIAL INSTRUMENT AND ID CODE        NOVO NORDISK B DK006010261
TYPE OF TRANSACTION                     SALE OF SHARES
DATE OF TRANSACTION                     30 OCTOBER 2008
PLACE OF TRANSACTION                    NASDAQ OMX COPENHAGEN
VOLUME OF TRANSACTION                   1,000 SHARES
TOTAL VALUE OF TRANSACTION              DKK 308,500


NAME                                    SOREN THUESEN PEDERSEN
REASON FOR REPORTING                    MEMBER OF THE BOARD OF DIRECTORS
FINANCIAL INSTRUMENT AND ID CODE        NOVO NORDISK B DK006010261
TYPE OF TRANSACTION                     PURCHASE OF SHARES
DATE OF TRANSACTION                     30 OCTOBER 2008
PLACE OF TRANSACTION                    NASDAQ OMX COPENHAGEN
VOLUME OF TRANSACTION                   200 SHARES
TOTAL VALUE OF TRANSACTION              DKK 60,000


DEFINITIONS AND BACKGROUND INFORMATION:

PUBLICATION

Publication shall take place the day after Novo Nordisk receives
sufficient information on the trading. Publication is only required when the
total amount of transactions of a specific board member/executive and his/her
associated persons in any one calendar year has reached 5,000 euros.


WHO ARE BOARD MEMBERS, EXECUTIVES AND ASSOCIATED PERSON?

Board members and executives are members of the Board of Directors and Executive
Management, respectively, of Novo Nordisk A/S. Associated persons are defined as
the following persons associated to a board member/executive: 1) spouse or
cohabitant, 2) children under the age of 18 years, 3) relatives defined as
brothers, sisters, parents, grandparents etc, children, grandchildren etc who
have shared the same household with a board member/executive for at least one
year, and 4) any legal person, including a company, a foundation or a
partnership, which is controlled directly or indirectly by a board
member/executive and/or a person mentioned in 1)-3), or to which a board
member/executive and/or a person mentioned in 1)-3) has managerial
responsibilities or economic interests substantially equivalent to the legal
person.

WHAT IS TRADING/TRANSACTION?

Trading is any kind of transaction, including shares purchased or otherwise
acquired, shares sold or otherwise disposed, gifts, mortgages and grants and
exercise of options, but not heritage.


WHAT IS FINANCIAL INSTRUMENT AND ID CODE?

Financial instrument includes shares listed on the NASDAQ OMX Copenhagen and
London Stock Exchange as well as ADRs listed on New York Stock Exchange, except
for ADRs held in 401(k) retirement plan by US-based employees. The ID code is
the code (ISIN DK006010261) of the Novo Nordisk share on the NASDAQ OMX
Copenhagen, the code (NVOB) on London Stock Exchange or the code (NVO) on New
York Stock Exchange.


WHAT IS DATE AND PLACE OF TRANSACTION?

Date of transaction is the actual transaction date. The place of transaction is
the actual place of transaction, ie NASDAQ OMX Copenhagen, London Stock Exchange
or New York Stock Exchange.

WHAT IS VOLUME AND VALUE OF TRANSACTION?

The volume of transaction is the number of shares (of DKK 1 nominal value) or
other financial instruments traded. The transaction value is the number of
shares traded multiplied by the transaction price. The exchange rate of the
Danish Central Bank (Nationalbanken) on the date of transaction is used for
calculating the transaction value in DKK in case of shares traded on London
Stock Exchange and ADRs listed on New York Stock Exchange.

Novo Nordisk is a healthcare company and a world leader in diabetes care. In
addition, Novo Nordisk has a leading position within areas such as haemostasis
management, growth hormone therapy and hormone replacement therapy. Novo Nordisk
manufactures and markets pharmaceutical products and services that make a
significant difference to patients, the medical profession and society. With
headquarters in Denmark, Novo Nordisk employs approximately 26,550 employees in
80 countries, and markets its products in 179 countries. Novo Nordisk's B shares
are listed on the stock exchanges in Copenhagen and London. Its ADRs are listed
on the New York Stock Exchange under the symbol 'NVO'. For more information,
visit novonordisk.com.


FOR FURTHER INFORMATION PLEASE CONTACT:

Media:                              Investors:

Outside North America:              Outside North America:
Elin K Hansen                       Mads Veggerby Lausten
Tel: (+45) 4442 3450                Tel: (+45) 4443 7919
E-mail: ekh@novonordisk.com         E-mail: mlau@novonordisk.com

                                    Hans Rommer
                                    Tel: (+45) 4442 4765
                                    E-mail: hrmm@novonordisk.com

In North America:
Sean Clements                       Kasper Roseeuw Poulsen
Tel: (+1) 609 514 8316              Tel: (+45) 4442 4471
E-mail: secl@novonordisk.com        E-mail: krop@novonordisk.com

Company Announcement no 69 / 2008







                                   SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf of the
undersigned, thereunto duly authorized.

Date: November 3, 2008                        NOVO NORDISK A/S
                             ---------------------------------------------------
                                            Lars Rebien Sorensen,
                                     President and Chief Executive Officer