Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Bienen Henry S
2. Date of Event Requiring Statement (Month/Day/Year)
07/24/2013
3. Issuer Name and Ticker or Trading Symbol
Onconova Therapeutics, Inc. [ONTX]
(Last)
(First)
(Middle)
C/O ONCONOVA THERAPEUTICS, INC., 375 PHEASANT RUN
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

NEWTOWN, PA 18940
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series I Convertible Preferred Stock   (1)   (1) Common Stock 9,156 $ (1) D  
Stock Option (right to purchase) 01/01/2010 01/02/2019 Common Stock 4,576 $ 5.76 D  
Stock Option (right to purchase) 01/16/2009 01/17/2019 Common Stock 375 $ 5.76 D  
Stock Option (right to purchase) 01/01/2011 01/02/2020 Common Stock 4,576 $ 5.76 D  
Stock Option (right to purchase) 01/01/2010 01/02/2020 Common Stock 375 $ 5.76 D  
Stock Option (right to purchase) 01/01/2012 01/01/2021 Common Stock 4,576 $ 6.13 D  
Stock Option (right to purchase) 12/31/2012 01/01/2022 Common Stock 4,726 $ 6.13 D  
Stock Option (right to purchase) 01/26/2012 01/26/2022 Common Stock 412 $ 6.13 D  
Stock Option (right to purchase) 02/01/2012 02/01/2022 Common Stock 412 $ 6.13 D  
Stock Option (right to purchase) 06/21/2012 06/22/2022 Common Stock 412 $ 7.53 D  
Stock Option (right to purchase) 07/03/2012 07/04/2022 Common Stock 412 $ 7.53 D  
Stock Option (right to purchase) 10/03/2012 10/04/2022 Common Stock 412 $ 13.28 D  
Stock Option (right to purchase) 12/17/2012 12/18/2022 Common Stock 412 $ 13.28 D  
Stock Option (right to purchase) 01/01/2014 01/02/2023 Common Stock 5,026 $ 13.28 D  
Stock Option (right to purchase) 01/01/2013 01/02/2023 Common Stock 7,501 $ 13.28 D  
Stock Option (right to purchase) 02/01/2013 02/02/2023 Common Stock 450 $ 13.28 D  
Stock Option (right to purchase) 03/14/2013 03/15/2023 Common Stock 450 $ 13.28 D  
Stock Option (right to purchase) 04/22/2013 04/23/2023 Common Stock 450 $ 14.74 D  
Stock Option (right to purchase) 04/26/2013 04/27/2023 Common Stock 450 $ 14.74 D  
Stock Option (right to purchase) 06/07/2013 06/08/2023 Common Stock 450 $ 14.74 D  
Stock Option (right to purchase) 06/11/2013 06/12/2023 Common Stock 450 $ 14.74 D  
Stock Option (right to purchase) 06/17/2013 06/18/2023 Common Stock 450 $ 14.74 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Bienen Henry S
C/O ONCONOVA THERAPEUTICS, INC.
375 PHEASANT RUN
NEWTOWN, PA 18940
  X      

Signatures

/s/ Ajay Bansal, as attorney in fact 07/24/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The convertible preferred stock is convertible at any time, at the holder's election, and is automatically convertible immediately prior to the consummation of the Issuer's initial public offering on a 0.75-for-1 basis and has no expiration date.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

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