SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                   FORM 12b-25

                        COMMISSION FILE NUMBER 001-14053


                           NOTIFICATION OF LATE FILING

                                  (Check One):
             |X| Form 10-K |_| Form 11-K |_| Form 20-F |_| Form 10-Q
                          |_| Form N-SAR |_| Form N-CSR


                       For Period Ended: December 31, 2005
                         ------------------------------

                       [ ] Transition Report on Form 10-K
                       [ ] Transition Report on Form 20-F
                       [ ] Transition Report on Form 11-K
                       [ ] Transition Report on Form 10-Q
                       [ ] Transition Report on Form N-SAR

                        For the Transition Period Ended:
                        ---------------------------------

Nothing in this form shall be construed to imply that the Commission has
verified any information contained herein.

If the notification relates to a portion of the filing checked above, identify
the Item(s) to which the
notification relates: Not Applicable

                                     PART I
                             REGISTRANT INFORMATION

                            MILESTONE SCIENTIFIC INC.
                            -------------------------
                             Full Name of Registrant


                            -------------------------
                            Former Name if Applicable

               220 South Orange Avenue, Livingston Corporate Park
               --------------------------------------------------
            Address of Principal Executive Office (Street and Number)
                               Livingston NJ 07039
                               -------------------
                            City, State and Zip Code






                                     PART II
                             RULES 12b-25(b) AND (c)

         If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed. (Check box if appropriate.)

|X| (a) The reasons described in reasonable detail in Part III of this form
could not be eliminated without unreasonable effort or expense;

|X| (b) The subject annual report, semi-annual report, transition report on Form
10-K, Form 20-F, Form 11-K, Form N-SAR or Form N-CSR, or portion thereof, will
be filed on or before the fifteenth calendar day following the prescribed due
date; or the subject quarterly report or transition report on Form 10-Q, or
portion thereof will be filed on or before the fifth calendar day following the
prescribed due date; and

|_| (c) The accountant's statement or other exhibit required by Rule 12b-25(c)
has been attached if applicable.

                                    PART III
                                    NARRATIVE

         State below in reasonable detail the reasons why Form 10-K, 11-K, 20-F,
10-Q, N-SAR, N-CSR or the transition report or portion thereof, could not be
filed within the prescribed time period.

         The filing of the registrant's Annual Report on form 10-KSB for the
year ended December 31, 2005 has been delayed because the registrant has had
turnover and changes in positions of personnel in its financial department,
extending the time necessary to review transactions. The registrant believes
that the Annual Report on Form 10-KSB for such period will be available for
filing on or before April 15, 2006.

                                     PART IV
                                OTHER INFORMATION

(1) Name and telephone number of person to contact in regard to this
notification

         Rosaline Shau                   (973) 535 2717
         -------------                   -----------------------------------
         (Name)                          (Area Code) (Telephone Number)

(2) Have all other periodic reports required under Section 13 or 15(d) of the
Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of
1940 during the preceding 12 months or for such shorter period that the
registrant was required to file such report(s) been filed? If answer is no,
identify report(s). |X| Yes |_| No

(3) Is it anticipated that any significant change in results of operation for
the corresponding period for the last fiscal year will be reflected by the
earnings statements to be included in the subject report or portion thereof? | |
Yes |X| No, except that the registrant expects to show increased revenues and
decreased losses in 2005 compared to the 2004 fiscal year.

If so: attach an explanation of the anticipated change, both narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.

                                       2



                            MILESTONE SCIENTIFIC INC.
                            -------------------------
                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Date  03/31/06                              By:  /s/ Rosaline Shau
                                                 ----------------------
                                            Name: Rosaline Shau
                                            Title: Chief Financial Officer

Instruction: The form may be signed by an executive officer of the registrant or
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.

                                    ATTENTION

Intentional misstatements or omissions of fact constitute Federal criminal
violations. (See 18 U.S.C. 1001)

                              GENERAL INSTRUCTIONS

1. This form is required by Rule 12b-25 of the General Rules and Regulations
under the Securities Exchange Act of 1934.

2. One signed original and four conformed copies of this form and amendments
thereto must be completed and filed with the Securities and Exchange Commission,
Washington, D.C. 20549, in accordance with Rule 0-3 of the General Rules and
Regulations under the Act. The information contained in or filed with the form
will be made a matter of public record in the Commission files.

3. A manually signed copy of the form and amendments thereto shall be filed with
each national securities exchange on which any class of securities of the
registrant is registered. 4. Amendments to the notifications must also be filed
on form 12b-25 but need not restate information that has been correctly
furnished. The form shall be clearly identified as an amended notification. 5.
Electronic filers. This form shall not be used by electronic filers unable to
timely file a report solely due to electronic difficulties. Filers unable to
submit a report within the time period prescribed due to difficulties in
electronic filing should comply with either Rule 201 or Rule 202 of Regulation
S-T or apply for an adjustment in filing date pursuant to Rule 13(b) of
Regulation S-T.


                                       3